Two distinct features of 53BP1 explain its essentiality for CSR; the ability to form stable oligomeric assemblies at DSB sites and the faculty to protect DNA ends against resection mediated by RIF1 and components of the SHLD complex23,24. It has been proposed that tetramerization (and higher-...
A significant reduction in the Atlantic Meridional Overturning Circulation and rapid northern Hemisphere cooling 8200 years ago have been linked to the final melting of the Laurentide Ice Sheet. Although many studies associated this cold event with the d
found to have a translocation that generated a fusion protein between 53BP1 and the platelet-derived growth factor (PDGF; [48]). Because, in this scenario, PDGF tyrosine kinase activity depends on the ability of its fusion partner sequences to form oligomers, it was proposed that 53BP1 coul...
Ca2+ may act as a noncompetitive inhibitor by noncompetitively binding to chemical groups other than the Alg17B active site to form a stable intermediate complex of the enzyme, the substrate and the noncompetitive inhibitor. This intermediate complex cannot be decomposed and inhibits the enzyme’s...
return render_template( "plot/index.html", jmoall=jmoall_plot, jmomonth=get_jmo_project_timesheet_by_month(year, month), jmomonthcategory=get_jmo_category_timesheet_by_month(year, month), jmomonthsubcategory=get_jmo_subcategory_timesheet_by_month(year, month), timesheet_by_week=get...
DNA template 12.3 ± 0.1 17.4 ± 0.7 59% The results are given as the mean ± SD of three independent measurements. See also Table S1. Strikingly, for the wild-type aptamer, 93%–100% of the Mn2+ added to the buffer side of the dialysis chamber was associated with the RNA after the...
These small molecular mass proteins form a stable complex with CDK1/2 and are essential for normal regulation of CDKs during the cell division cycle and for degradation of p27kip1. Despite the high degree of homology between the nine known CDKs, only CDK1, CDK2 and, to a lesser extent...
1785.Minimum Elements to Add to Form a Given Sum 1786.Number of Restricted Paths From First to Last Node 1787.Make the XOR of All Segments Equal to Zero 1788.Maximize the Beauty of the Garden 1789.Primary Department for Each Employee 1790.Check if One String Swap Can Make Strings Equal 17...
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53BP1 and γH2AX form IRIF with same mean size of (540 ± 40) nm after high LET irradiation while the size after low LET irradiation is significantly smaller. The IRIF of both repair factors show nanostructures with partial anti-correlation. These structures are related to domains ...