Amino Acid SequenceCleavage of preprolactin (pPL) by detergent-solubilized signal peptidase produced mature prolactin and two small peptides derived from the signal peptide region of the pPL molecule. The production of both peptides was dependent on functional signal peptidase; the peptides were not...
Amino acid sequences were aligned with assistance from Clustal W 1.83 on the DDBJ web site. The arrow indicates the putative primary cleavage site of the signal peptide of bPRP-VII. LD1, 2, 3, and 4 refer to the conserved domain in the prolactin family. Full size image Figure 4 ...
Lactotroph cells in the pituitary gland secrete prolactin, a 23 kDa peptide hormone [79]. Its expression in rats begins in the middle to late stages of pregnancy, continues through nursing, and then drops during the early stages of involution [80]. The plasma level of prolactin in cattle, ...
While GAP inhibits prolactin secretion in rats, its physiological function in other mammals remains unknown. GnRH initiates neuroendocrine processes that regulate gametogenesis, gonadal steroid production, and pituitary hormone release [21]. The coding region and signal peptide sequence of GnRH genes ...