Keratomas are space-occupying masses of abnormal horn tissue that lead to pressure necrosis of the 3rd phalanx bone, causing a well-demarcated lucency typically on the solar margin of the bone. It should not be confused with the crena, a normal anatomical feature on the distal aspect of the...
In genetic engineering, bone tissue-targeted ligands are displayed on the EV source cell membrane through a plasmid vector. BMSCs in the bone marrow highly express SDF1, which can recruit CXCR4 to peripheral HSCs for homing and promote bone metastasis in several CXCR4-positive tumor cells.187Co...
After removing the periosteum and bone marrow, the remaining bones were physically crashed to small pieces using a tissue homogenizer and then subjected to digestion by collagenase II (; Gibco) for 3 h at 37 °C. The digested tissues were filtered through 70-µm nylon mesh membranes (...
Figure 1. Schematic diagram of different approaches to obtain Mesenchymal stem cells. MSCs can be derived from either iPSCs, ESCs, or adult mesenchymal tissue. MSCs can be obtained by ESCs and iPSCs using small molecules such as mitogen-activated protein kinase (MEK) inhibitor, (MEK) inhibitor...
Interest in obtaining bioactive glasses in the form of nanoparticles has been increasing in the recent decades due to their potential applications in bone tissue regeneration, soft tissue applications, and wound healing. Moreover, the development of sol–gel chemistry has provided new possibilities for...
infection of the soft tissue and bone, and breakage of the fillers with or without particulate formation. Considering the adverse reaction, surgeons often prefer established techniques due to a proven track record, which leads to the limited utilization of bone void fillers, hampering market growth...
A prediction from the above findings is that breast cancer cells with a high level of pY416-Src have a particular survival advantage in the bone marrow because CXCL12 and IGF1 are relatively more abundant in this tissue than in other organ sites (Zhang et al., 2009). Indeed, when inoculat...
They can also differentiate into osteoblasts, adipocytes, chondrocytes, muscle cells, and even nerve cells. Moreso, the cells have been found to possess less immune rejection, easy access, and value-added ability. As a result, they have become an ideal cell for bone tissue engineering [2–5...
[23,24]. Major improvements were seen during the last two decades, and currently the application of ToF-SIMS to the analysis of tissue sections and single cells is quickly advancing [25,26]. Several groups have shown that ToF-SIMS is a powerful technique to characterize cells [27] and to...
FIG. 1 is a schematic diagram of the method of the invention. Crystals of a water-dissolvable material, preferably a salt such as sodium chloride, are milled into a controlled size selected depending on the type of tissue desired to be replaced. The pore size of the salt crystals should be...