Del Giovane C, van Heemst D, Quinn T, Kearney PM, Westendorp RGJ, Gussekloo J, Mooijaart SP, Hans D, Bauer DC, Rodondi N, Aeberli D (2022) Bone geometry in older adults with subclinical hypothyroidism upon levothyroxine therapy: a nested study within a randomized placebo controlled trial...
However, MM remains fatal as nearly all patients ultimately become refractory to various lines of therapy. A greater understanding of how resistant MM emerges in the clinical setting can yield new treatment strategies to slow relapse times and extend the efficacy of standard of care therapies. In ...
This effect has been observed in numerous clinical trials pertaining to the treatment to the treatment of postmenstrual osteoporosis with NAF therapy. For instance, a three-year study involving daily NaF supplementation of 30 mg did not significantly affect bone mineral density (BMD) [181]. However...
Depending on the therapy used, side-effects vary. Many different drugs or drug combinations can be used to treat bone pain caused by bone cancer. These drugs may be used in combination with surgery, radiation, and other treatments which can affect the way the body handles medication, as well...
adding TKIs as maintenance therapy following chemotherapy has not been evaluated in relapsed disease. Decision-making in the absence of evidence of benefit must be balanced with potential toxicity and the need for repeated hospital visits in a disease setting where the median OS is approximately one...
In lactating mothers, the high calcium (Ca2+) demand for milk production triggers significant bone loss1. Although oestrogen normally counteracts excessive bone resorption by promoting bone formation, this sex steroid drops precipitously during this post
Predictive biomarkers can predict a patient's response to treatment or be used for monitoring during treatment to determine if the patient is benefiting from the therapy [75]. Proteins CAPG and GIPC1 have been confirmed to have prognostic significance by Westbrook et al. In the same study, the...
[42] incorporated magnetic SrFe12O19nanoparticles into bioglass/chitosan scaffolds to fabricate multi-functional hybrid scaffolds for photothermal tumor therapy and subsequent bone regeneration. The excellent photothermal conversion property of SrFe12O19endowed the hybrid scaffolds with great efficiency in ...
Furthermore, it underscored how the metastatic microenvironment has the capacity to restore this malignant property of cancer cells, particularly during hormone therapy. This finding sheds valuable light on the mechanisms underlying hormone therapy resistance and provides insights into the dynamic interplay ...
These findings suggest that immunohistochemistry for ROS1 may be useful to confirm the diagnosis of a subset of IMTs, and also raise the possibility that some patients with clinically aggressive ALK-negative IMTs may be candidates for targeted therapy directed against ROS1. Whether the pattern of ...