However, MM remains fatal as nearly all patients ultimately become refractory to various lines of therapy. A greater understanding of how resistant MM emerges in the clinical setting can yield new treatment strategies to slow relapse times and extend the efficacy of standard of care therapies. In ...
Del Giovane C, van Heemst D, Quinn T, Kearney PM, Westendorp RGJ, Gussekloo J, Mooijaart SP, Hans D, Bauer DC, Rodondi N, Aeberli D (2022) Bone geometry in older adults with subclinical hypothyroidism upon levothyroxine therapy: a nested study within a randomized placebo controlled trial...
Clinical maintenance therapy with Li level at 0.6–1.2 mmol/L for an average of 8 years could preserve or enhance the bone density by decreasing the bone turnover state [100]. This therapeutic range could be established by daily supplementation of at least 200 mg Li [101]. There was also...
These findings suggest that immunohistochemistry for ROS1 may be useful to confirm the diagnosis of a subset of IMTs, and also raise the possibility that some patients with clinically aggressive ALK-negative IMTs may be candidates for targeted therapy directed against ROS1. Whether the pattern of ...
In lactating mothers, the high calcium (Ca2+) demand for milk production triggers significant bone loss1. Although oestrogen normally counteracts excessive bone resorption by promoting bone formation, this sex steroid drops precipitously during this post
Predictive biomarkers can predict a patient's response to treatment or be used for monitoring during treatment to determine if the patient is benefiting from the therapy [75]. Proteins CAPG and GIPC1 have been confirmed to have prognostic significance by Westbrook et al. In the same study, the...
85 The latter experimental evidence has an iatrogenic parallel in humans: fetuses and neonates who receive allogeneic blood transfusions as therapy for Rh hemolytic disease may undergo engraftment of viable transfused cells, sometimes leading to GVHD and even to specific tolerance of skin grafts.86,...
I got hip x-rays and a lumbar MRI, which didn’t show the herniated disc that the doctor suspected. I started physical therapy, but a sneeze one night in February, and daring to sit on the loo the next morning caused an injury that landed me in the emergency room. ...
Hematological diseases. Amongst the hematological diseases, MPN have been historically associated with modification of the BM microenvironment in the clinical setting. In these disorders, investigating the role of ECs could shed light on their potential contribution to disease development and progression. ...
In the last few years, hyperthermia therapy induced by light, electrical and magnetic stimulation has attracted extensive attention in biomedical fields [184,185,186]. In particular, the near-infrared (NIR) light in the wavelength of 700 to 1300 nm is utilized in the biomedical engineering field...