the intrinsic spatial, biomolecular, and mechanotransduction complexities in bone remodeling continue to be debated. Initially, a two-stage process involving two types of cellular machinery was considered to be responsible for bone remodeling, in which bone formation by osteoblasts follows bone resorption...
Bone remodelingThe dynamic nature of the skeleton is achieved by a process called "remodeling" which involves the co-ordinated actions of osteoclasts, osteoblasts, osteocytes within the bone matrix and osteoblast-derived lining cells that cover the surface of bone. Remodeling commences with signals ...
Once encapsulated in human fibrin and exposed to analogue microgravity for 5 days, masses of bone can be observed being lost from the initial structure, allowing to simulate the bone loss process further. Constructs can function as multicellular, organotypic units. Large osteocytic projections and ...
The final step of fracture repair is known as the remodeling phase. At this stage the callus begins to mature and remodel itself. Woven bone is remodeled into stronger lamellar bone by the orchestrated action of both osteoblast bone formation cells and osteoclast bone resorption cells. The nutriti...
Fig. 5. Schematic illustration of the normal bone remodeling process. Bone mineralization is based on type I collagen as a scaffold, under the synergistic adjustment of mineral salts, non-collagen, proteoglycan, glycoprotein and related enzymes [84,86]. Bone mineralization occurs in two steps [92...
Breast cancer frequently metastasizes to the skeleton, interrupting the normal bone remodeling process and causing bone degradation. Osteolytic lesions are... YC Chen,DM Sosnoski,AM Mastro - 《Breast Cancer Research》 被引量: 183发表: 2010年 Bone metastasis in prostate cancer: molecular and cellu...
Osteoporosis refers to the loss of bone density resulting from an altered balance of the bone remodeling process, and affects approximately 10 million US adults 50 years of age and older [18]. The most widely used osteoporosis treatment is the administration of bisphosphonates, which shorten the ...
The process of bone repair During bone repair, a variety of processes need to be coordinated and these can be grouped in four different stages: the inflammation response, the formation of the soft and the hard callus and the remodeling of the bone (Fig.1) [18,19]. Inflammation, which is...
The HCA model recapitulates the key steps of trabecular bone remodeling Trabecular bone remodeling is a continuously occurring process that is essential for regulating calcium homeostasis and bone injury repair (Fig. 1a)32,33. This process occurs throughout the skeleton at individual sites known as ...
Bone remodeling: an operational process ensuring survival and bone mechanical competence Article Open access 18 July 2022 Skeletal stem and progenitor cells in bone physiology, ageing and disease Article 08 October 2024 Mesenchymal stromal cell-derived septoclasts resorb cartilage during developmental...