Adamantinoma, an uncommon low-grade primary malignant bone tumor, rarely causes leg pain in adolescents and typically manifests in the lower extremities, with a notable preference for the tibia, although occurrences in other bones such as the femur, fibula, and pelvis have been documented. ...
5indicating the underlying linkage between SBMLs and OA progression. The worsening of SBMLs based on MRI manifestations is associated with subsequent radiographic findings and persistent pain.7,8,9At the site of an SBML, a high in situ turnover ...
Is osteoporosis really a silent disease without bone pain and tenderness unless a fracture occurs? Our aim in this study was to answer the question by assessing the questionable tenderness on tibia bones of fracture-free patients with low bone density and to compare the findings with a normal ...
Cells damaged from the trauma of fracture release large amounts of inflammatory prostaglandins at the site of fracture. The ensuing inflammation causes pain and the natural tendency is to want to block this painful reaction. In this case, non-steroidal anti-inflammatory drugs (COX-1 and COX-2 ...
Keywords: bone pain; osteoclasts; osteoblasts; bone metastasis; skeletal-related events 1. The Healthy Bone Tissue Despite its hard nature, due to the deposition of hydroxyapatite crystal in the extracellular matrix, bone undergoes several cycles of renewal during the life of each individual, which ...
(tibia) and thigh bone (femur). But it can also form in the bones of your arms, hands, feet, ankles, and spine. It's most common in people aged 5-25 years, and it's about three times more common in boys and people assigned male at birth than in girls and people assigned female...
Zylla D, Steele G, Gupta P (2017) A systematic review of the impact of pain on overall survival in patients with cancer. Support Care Cancer 25:1687–1698. https://doi.org/10.1007/s00520-017-3614-y Article PubMed Google Scholar Coleman RE, Croucher PI, Padhani AR, Clézardin P, ...
Results The tibia tissue of nude mice in Control group and sh-NC group was destroyed, the continuity of bone cortex was interrupted, obvious bone tumor lesions were observed, the tumor cells were irregular in shape, densely distributed and disordered, and the nuclei were obviously deformed. ...
We previously demonstrated that the chemokine receptor CXCR4 plays an important role in cancer-induced bone pain by activating spinal neurons and glial cells. However, the specific neuronal mechanism of CXCR4 signaling is not clear. We further report that CXCR4 contributes to the activation of the...
area on MRI increases, particularly in the medial tibia plateau and medial condyle, presenting a strong relationship with the loss of cartilage volume in corresponding regions.12Recent clinical data have shown the strong association between BMLs and cartilage damage in the tibial plateau, indicating ...