A bone marrow tumor is a type of tumor that originates in the bone marrow, which can be a result of abnormal cell growth within the bone tissue. AI generated definition based on:Imaging of Pain,2011 About this page Add to MendeleySet alert ...
Interestingly, mir-17–92-deficiency in B cells leads to enhanced homing of plasma cells to the bone marrow during T-cell-dependent immune response and selectively impairs IgG2c production. Mechanistically, mir-17–92 directly represses the expression of Sphingosine 1-phosphate receptor 1 and ...
Contrary to SFRP2, which facilitates infiltration and the metastasis of osteosarcomas [258], SFRP3 is downregulated in osteosarcoma patients at the local and systemic levels [456] and upregulated in bone marrow multiple myeloma samples with advanced lytic bone disease (LBD) as compared to no/...
Multiple myeloma (MM), characterized by the accumulation of clonal malignant plasma cells in the three-dimensional bone marrow niches, represents 10% of all hematologic malignancies [6]. Although the recent advances in various therapeutic modalities have improved the 5-year survival of MM patients ...
2.3. Cell Viability Equal numbers of bone marrow derived macrophages (BMMs) as prepared above were seeded to determine cell viability by the MTT assay as described [24]. 2.4. RNA Isolation and Quantitative Polymerase Chain Reaction (qPCR) Total RNA was isolated using QIAzol reagent as described ...