Osteoarthritis (OA) is considered a multifactorial disease whose development and progression may include several structural abnormalities aside from cartilage destruction. Bone marrow lesions (BMLs) have been reported to be associated with OA pathology, and several studies have advocated its close ...
(2017). Bone Marrow Lesions in Osteoarthritis: What Lies Beneath. J Orthopaedic Res. doi: 10.1002/ jor.23844 (Epub ahead of print).Hernandez Christopher J.,Alliston Tamara,Felson David T.,etc.Bone marrow lesions in osteoarthritis: What lies beneath[J].2018,36(7)....
Bone marrow lesions may not respond to anti-inflammatory treatments in knee osteoarthritis(OA)OrthoticSplintCMCOsteoarthritisObjective: Osteoarthritis (OA) is a non-rheumatologic joint disease characterized by progressive degeneration of the cartilage extra-cellular matrix (ECM), enhanced subchondral bone ...
Basic and clinical research on osteoarthritis has been carried out for decades, but many questions remain unanswered. The exact role of subchondral bone during the initiation and progression osteoarthritis remains unclear. Accumulating evidence shows that subchondral bone lesions, including bone marrow ...
Bone marrow lesions (BMLs) on magnetic resonance (MR) images in knee osteoarthritis patients are considered to predict the severity and progression of the disease. We evaluated the histological findings of BMLs on MR images of the subchondral area of the medial femoral condyle in varus ...
12 BONE MARROW LESIONS FROM OSTEOARTHRITIS KNEES ARE CHARACTERIZED BY SCLEROTIC BONE THAT IS LESS WELL MINERALIZED Author links open overlay panelD.J. Hunter, E. Morgan, L. Gerstenfeld, G. Bishop, P. McCree, T. Einhorn, R.A. Maciewicz, P. NewhamShow more Add to Mendeley Share Cite...
Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized Newham P, Foster M, Jackson S, Morgan EF: Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized... DJ Hunter,G Lou,G Bishop,....
such as synovitis and bone marrow lesions, in patients with erosive hand OA.139TNF-α has two high-affinity and specific receptors: TNFR1 and TNFR2. These two receptors are differentially expressed and seem to have distinct functions. TNFR1 is expressed by nearly all cell types and primarily ...
(MRI) further enabled the identification of bone marrow lesions (bone marrow edema),173which seem to occur underneath severely degraded cartilage152,174and strongly associate with progressive cartilage loss.175,176,177Increasing evidence supports the use of bone marrow lesions as a powerful predictor ...
Individuals with bone marrow lesions (BMLs) on their MRI scan were found to have osteoarthritis that progressed more rapidly than those that did not. On average, the space within the joint is lost at a rate of 0.15mm per year however the Southampton study shows that, overall, individuals wi...