Hematopoietic stem cells (HSCs) in the endosteum of mesoderm-derived appendicular bones have been extensively studied. Neural crest-derived bones differ from appendicular bones in developmental origin, mode of bone formation and pathological bone resorption. Whether neural crest-derived bones harbor HSCs ...
(2018). Mobilization of hematopoietic stem cells as a result of innate immunity-mediated sterile inflammation in the bone marrow microenvironment-the involvement of extracellular nucleotides and purinergic signaling. Leukemia, 32, 1116-1123. https://doi.org/10.1038/s41375-018-0087-z....
Umbilical cord blood (UCB) is a promising modality for hematopoietic stem cell transplantation (HSCT) but is limited by cell yield from UCB units. This issue of cell dose can be addressed by improving homing of UCB stem/progenitor cells to the bone marrow (BM). Erythropoietin (EPO) receptor...
或Human Bone Marrow Derived Hematopoietic Stem/Progenitor Cells),具备庞大的供体库,为复杂研究提供了更多便利性,不论是需要单一供体大量细胞的研究,还是对不同年龄、性别、种族供体细胞间差异的研究,均可获得理想的细胞产品。
8, 9 In addition to providing critical cell-cell contact, MSCs produce growth factors for hematopoiesis and may attract infused hematopoietic stem cells to the marrow by inducing homing receptors. In a nonobese diabetic/severe combined immunodeficiency (NOD/SCID) system Peled et al showed that ...
Hematopoietic stem cells (HSCs) are critical for maintaining lifelong blood production and immune function, especially in the context of bone marrow transplantation, where their ability to reconstruct multiple blood lineages is essential. However, recent
2) bone marrow hematopoietic stem cells 骨髓造血干细胞 1. Method:The bone marrow hematopoietic stem cells were isolated from non obese diabetic mice by means of magnetic activated cell sorting(MACS) using the stem cell antige 1(Sca-1) expressed on the surface of hematopoietic stem cells. ...
Bone Marrow CellsHematopoietic Stem CellsInsulin-Like Growth Factor IFibroblast Growth Factor 2Granulocyte-Macrophage Colony-Stimulating FactorInterleukin-3Membrane GlycoproteinsHAEMATOPOIETIC stem cells are a population of cells capable both of self renewal and of differentiation into a variety of ...
imaging of transplanted hematopoietic stem and progenitor cells (HSPCs) was developed to investigate the relationship between HSPCs and components of their microenvironment in the bone marrow. In particular, it allows a direct observation of the behavior of hematopoietic cells during the first few days...
Liver-derived fetal hematopoietic stem cells selectively and preferentially home to the fetal bone marrow. Blood 1993;81 :399-404.Zanjani ED, Ascensao JL, Tavassoli M. Liver-derived fetal hematopoietic stem cells selectively and preferentially home to the fetal bone marrow. Blood. 1993;81:399-...