1、(P1)Multipotent stromal cells (MSCs) and their osteoblastic lineage cell (OBC) derivatives are part of the bone marrow (BM) niche and contribute to hematopoietic stem cell (HSC) maintenance. Here, we show that myeloproliferative neoplasia (MPN) progressively remodels the endosteal BM niche int...
Hematopoietic stem cells (HSCs) in the endosteum of mesoderm-derived appendicular bones have been extensively studied. Neural crest-derived bones differ from appendicular bones in developmental origin, mode of bone formation and pathological bone resorption. Whether neural crest-derived bones harbor HSCs ...
北京泽平代理的美国进口LONZA人骨髓造血干细胞(Human Bone Marrow CD34+ Stem/Progenitor Cells,或Human Bone Marrow Derived Hematopoietic Stem/Progenitor Cells),具备庞大的供体库,为复杂研究提供了更多便利性,不论是需要单一供体大量细胞的研究,还是对不同年龄、性别、种族供体细胞间差异的研究,均可获得理想的细胞产品。
Stem Cell DiscoveryDavy, P., Brienne Walker, B., Wong, L. and Allsopp, R. (2013) Hematopoietic stem cells are a critical sub-popu- lation of whole bone marrow in the treatment of myocar- dial infarction. Stem Cell Discovery, 3, 117-126. http://dx.doi.org/10.4236/scd.2013.32016...
Hematopoietic stem cells are multipotent, myelolymphoid stem cells, which serve as a source of hematopoietic cells. Notes In human, HSC from the fetal liver colonize the bone marrow during the sixth month. These precursors are Lin- (lineage-negative), meaning that they lack detectable surface...
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for multiple disorders, but deficiency and dysregulation of T cells limit its utility. Here we report a biomaterial-based scaffold that mimics features of T cell lymphopoiesis in the bone marrow. The bone marrow cryogel...
Hematopoietic stem cells (HSCs) in the endosteum of mesoderm-derived appendicular bones have been extensively studied. Neural crest-derived bones differ from appendicular bones in developmental origin, mode of bone formation and pathological bone resorpt
2. Diabetes Mellitus Alters Bone Marrow Endothelial Cells 骨髓微环境对HSC的调控 Haematopoietic stem cell activity and interactions with the niche Fig 3A:为了探究myelopioesis的机制,作者首先分选了different niche cells(以下三种细胞) 内皮细胞:Lin-CD45-CD31highSca-1high ...
The bone marrow consists of (1) hematopoietic stem cells, pluripotent cells capable of self-renewal; (2) progenitor cells that evolve into more differentiated cells with each cell division; (3) precursor cells that can be identified by light microscopy (not shown, see Fig. 13-3); and (4)...
(2018). Mobilization of hematopoietic stem cells as a result of innate immunity-mediated sterile inflammation in the bone marrow microenvironment-the involvement of extracellular nucleotides and purinergic signaling. Leukemia, 32, 1116-1123. https://doi.org/10.1038/s41375-018-0087-z....