However, the transcriptome profile of rat genes in bone marrow-derived macrophages (BMM) at different activation statuses has not been reported. Therefore, we performed RNA-Sequencing to identify gene expression signatures of rat BMM polarized in vitro with different stimuli. The differentially ...
To investigate the primary defects and development of macrophages in MRL/MpJ-1pr/1pr (MRL/1) mice, we used a pure population of macrophages derived from bone marrow precursor cells cultured in the presence of L-cell conditioned medium (LCM) as a source of colony stimulating factor. Bone ...
15 February 2016 Published: 04 March 2016 Age-associated metabolic dysregulation in bone marrow- derived macrophages stimulated with lipopolysaccharide Fan Fei1,2, Keith M. Lee2, Brian E. McCarry1 & Dawn M. E. Bowdish2 Macrophages are major contributors to age-associated infla...
The nuclear orphan receptor Nur77 (NR4A1, TR3, or NGFI-B) has been shown to modulate the inflammatory response of macrophages. To further elucidate the role of Nur77 in macrophage physiology, we compared the transcriptome of bone marrow-derived macrophag
4R 12 BMDM BMDM+MSC 10 *** 8 6 4 2 0 5h 24h 48h IL-4 CD206 14 BMDM BMDM+MSC 12 ** 10 8* 6 4 2 0 5h 24h 48h IL-4 Figure 2 The modulatory effect of mesenchymal stem cells (MSCs) on the phenotype of bone marrow-derived macrophages (BMDMs) at the transcriptional level....
[26,27,28]. Knockdown of YAP1 in bone marrow-derived macrophages (BMM) downregulated osteoclastogenesis, decreased osteoclastic activities and reduced the formation of F-actin sealing zone in resorptive pits [26]. Besides, disruption of YAP/TEAD association by Verteporfin also impaired the NF-κB...
Bone marrow–derived monocytes/macrophages (BMMs) play a vital role in liver inflammation and fibrogenesis. Cannabinoid receptor 1 (CB1) mediates the recruitment of BMMs into the injured liver. In this study, we revealed the molecular mechanisms under CB1‐mediated BMM infiltration. Carbon ...
Herein, we used bone marrow macrophages derived from adult male CCR3-proficient and CCR3-deficient mice to study the role of CCR3 in osteoclast formation and activity. CCR3 deficiency was associated with formation of giant hypernucleated osteoclasts, enhanced bone resorption when cultured on bone ...
bone marrow-derived macrophages (BMMs) by blocking the BMP-2/Smad/Id1 signaling pathway.130The polysaccharide ASP-2 derived from the root ofAcorus tatarinowii Schottinhibits osteoclast differentiation and attenuates LPS-induced bone loss in mice by inhibiting the PLCγ2-Ca2+signaling axis.131Fucos...
bone marrow-derived macrophages (BMMs) by blocking the BMP-2/Smad/Id1 signaling pathway.130The polysaccharide ASP-2 derived from the root ofAcorus tatarinowii Schottinhibits osteoclast differentiation and attenuates LPS-induced bone loss in mice by inhibiting the PLCγ2-Ca2+signaling axis.131Fucos...