Bone marrow biopsy sections are evaluated for the estimation of bone marrow cellularity and for the identification of pathological processes, such as primary hematologic disorders, granulomatosis, amyloidosis, fibrosis, osteosclerosis, and metastasis. Biopsy sections are routinely stained with hematoxylin and...
Cellularity decreased with age=67.6 – (age X 0.36). Conclusions Marrow cellularity from MRI shows statistically significant correlation with biopsy and significant differences between vertebral levels and changes with age.doi:10.1016/j.clinimag.2015.11.018George R. Matcuk Jr....
found that the cellularity of paediatric BM, including healthy donors, was the highest in patients younger than 2 years (~80%), declined to ~60% by the age of 5 years and then remained relatively constant in patients aged 5–18 years [26]. Furey et al. showed that the median CD34+ ...
by 6 months of age, when recombination in LepR+cells was nearly complete, we observed virtually no nerve fibres in the bone marrow ofLeprcre/+; Ngffl/∆
Studies on the structure and function of bone marrow. II. Variations in cellularity in various bones with advancing years of life and their relative response to stimuli. J Lab Clin Med 1932;17:960–962. Google Scholar Hartsock RJ, Smith EB, Petty CS. Normal variations with aging of the ...
The total marrow cellularity, using 59Fe as a marrow label, has been measured by an in vivo technique including suppression of radioiron reutilization by inactive iron. The blocking efficacy was studied from the red cell incorporation of 55Fe given after marrow sampling. The error of the method...
By looking at 3D reconstructed BM images, Braunig and colleagues have analyzed BM cellularity, megakaryocyte (MK) volume, and vessel volume, revealing distinct alterations in MPN samples compared to age- and gender-matched controls [125]. Particularly, Polycythemia vera (PV) samples exhibited no si...
. Finally, cellularity and vascularity at the interface gradually decrease, and the collagen fibers are mostly parallel to each other in the maturation phase, indicating gradual restoration of the biomechanical strength of the interface. Current biological treatments for promoting tendon–bone healing...
Malignancies that begin in the bone marrow can be divided into: (i) blood cancers that develop from the blood-forming cells of the marrow [6–8], and (ii) primary bone cancers, commonly known as sarcomas, that form as solid tumors by the bone tissue cells themselves [9,10]. The most...
In aspirate smears, the cellularity is generally determined by examining as many marrow particles as possible and estimating the area occupied by hematopoietic cells versus the area occupied by fat. However, it should be recognized that fat may not have replaced hematopoietic cells in some disord...