skin and bone marrow, CSCs existing in thebulkof tumors have the capacity to self-renew and differentiate into other cells. CSCs can renew themselves to induce resistance to external stimuli and can remain dormant for a long period in cancers. This explains why some cancers can still recur aft...
While the rates of both leukemia and lymphoma are slightly higher in Whites than Blacks, there have been some new developments in research in these two types of bone marrow cancers.Ebony
Erez and colleagues found that human breast cancers also contain fibroblasts lacking PDGFRα, suggesting that human tumors may also recruit bone marrow-derived cells. Moreover, tumors containing lower levels of PDGFRα tended to be more deadly, suggesting that the recruitment of bone marrow-derived ...
CXCR4, a G-protein-coupled receptor for the CXCL12 homeostatic chemokine promoting cell trafficking including the colonization of hematopoietic stem cells in bone marrow67, the homing of tumor cell to organs with high levels of CXCL12 (e.g. lymph nodes, lungs, liver, and bone marrow), and bo...
Human Mesenchymal Stromal/Stem Cells (MSCs) are adult multipotent cells that behave in a highly plastic manner, inhabiting the stroma of several tissues. The potential utility of MSCs is nowadays strongly investigated in the field of regenerative medicin
Subsequent cancers following non-myeloablative conditioning for allogeneic hematopoietic cell transplantation Phuong Vo Kevin Ng Rainer Storb Article26 Apr 2025 Favorable outcomes and the association between dynamic transfusion dependence and IPSS-M in MDS-h and MDS-LB patients undergoing allo-HSCT ...
et al. Fear of recurrence and its impact on quality of life in patients with hematological cancers in the course of allogeneic hematopoietic SCT. Bone Marrow Transplant 49, 1217–1222 (2014). https://doi.org/10.1038/bmt.2014.139 Download citation Received23 January 2014 Revised06 May 2014 ...
However, controversy exists as to whether CSCs arise from bone marrow-derived cells (BMDCs). In the present study, n-nitrosodiethylamine (DEN) was used to induce tumor formation in female mice that received bone marrow from male mice. Tumor formation was induced in 20/26 mice, including 12 ...
MSC primary cultures from human bone marrow (BM) and placenta (PL) were derived and verified by their immunophenotype standard pattern and trilineage differentiation potential. Then, a broad characterization of the transcriptome of these MSCs was performed using RNA deep sequencing (RNA-Seq). Quantit...
(Basel, Switzerland) under the trade names Zometa, Zomera, Aclasta, and Reclast) is a bisphosphonate given intravenously. Zometa is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer, as well as for treating osteoporosis. It can also be ...