Autologousbone marrow transplantis often used to restore a person's hematologic system after receivingradiation therapyfor cancer treatment. Radiation exposure damages the system, which produces all of the body's blood cell types - including those vital to immune system function. In clinical hematopoiet...
D-Ala contributed by beneficially modifying specific kinetic steps and thus improving enzyme activity and the cytotoxic effect, thus demonstrating that D-Ala may be a novel tool for cancer treatment that exploits the production of H2O2. More recent studies have used this D-Ala-mediated approach to...
In MM and other cancers, the tumor microenvironment is a well-known contributor to the development of treatment resistance5,6,7,8,9,10. MM is an archetype of cancer cell-stroma interactions whereby MM cells reside and metastasize systemically within the bone marrow microenvironment11. In the bon...
Various protocols have been used at Memorial Sloan-Kettering Cancer Center to improve the results of autologous bone marrow transplantation (ABMT) for hematopoietic malignancies. Results suggest that patients who undergo ABMT while in complete remission (after induction or reinduction treatment) do better...
The scaffold showed good mechanical properties, and the rabbit's bone marrow stromal cells grew, proliferated, and differentiated on the surface of the scaffold after adherence. In vivo experiments also demonstrated that the bone scaffolds showed high biocompatibility [34]. One study introduced osteo...
Sclerostin (SOST) is an endogenous inhibitor of bone formation, and an attractive target for treatment of osteoporosis. However, it is unclear whether SOST can be used as a therapeutic target for bone metastases of breast cancer, and whether small molecule compounds that target SOST in breast ...
Bone marrow mesenchymal stem cells-derived exosomal miR-29b-3p regulates aging-associated insulin resistance. ACS Nano. 2019;13:2450–62. CAS PubMed Google Scholar Thomou T, Mori MA, Dreyfuss JM, Konishi M, Sakaguchi M, Wolfrum C, Rao TN, Winnay JN, Garcia-Martin R, Grinspoon SK, ...
Researchers at The Tisch Cancer Institute at Mount Sinai have identified a treatment that is effective and safer than the standard of care for a serious, and sometimes fatal, side effect of bone marrow transplant in cancer patients. Results from a phase
“Extracellular calcium and bone diseases”, bone microenvironment is reshaped to tolerate tumour growth. Taking advantage of their high affinity to the bone tissue, calcium-based nanomaterials can serve as a delivery platform for efficient anticancer drug delivery in bone cancer treatment, Moreover, ...
It plays an important function in body support, tolerance of force damage and the protection of internal vital organs, as well as providing a stable circulation environment for the bone marrow [1,2,3,4]. Normally, bone has a certain regenerative potential over time in the face of minor ...