Eosinophils are involved in tissue homeostasis. Herein, we unveiled eosinophils as important regulators of bone homeostasis. Eosinophils are localized in proximity to bone-resorbing osteoclasts in the bone marrow. The absence of eosinophils in ΔdblGATA
In MM, isolation of tumour DNA requires collection of bone marrow (BM) aspirates using a large gauge needle to penetrate muscle and bone that may be difficult, painful and associated with significant patient anxiety as well as rare but significant complications including bleeding and infection. To...
Systemic chronic hypoxia is a feature of many diseases and may influence the communication between bone marrow (BM) and gut microbiota. Here we analyse patients with cyanotic congenital heart disease (CCHD) who are experiencing chronic hypoxia and characterize the association between bone marrow mesench...
Isolation of pure extracellular vesicles (EVs), especially from blood, has been a major challenge in the field of EV research. The presence of lipoproteins and soluble proteins often hinders the isolation of high purity EVs upon utilization of convention
(d) Bone marrow biopsy showing small number of borderline myeloid series elements (IHCX200) in paratrabecular area with myeloperoxidase (MPO). (e,f) Chromogranin-positive neuroblastoma cells infiltrating bone marrow (A: IHCX200; B: IHCX400). Samples of BMA for MFC analysis were collected in...
A targeted approach in managing osteoporosis’ risk within this demographic is imperative, advocating for the integration of specialized renal disease evaluation, including kidney biopsy, into osteoporosis care protocols, alongside the established laboratory evaluations for osteoporosis secondary causes. 3.2. ...
It is worthy of note that cancer cells can remain quiescent in bone marrow for several years until some stimuli determine their reactivation with consequent spreading and formation of a secondary lesion to the bone, to other organs, or to the site of the primary tumor [8,10]. One of the ...