Little is known about how leukemia cells alter the bone marrow (BM) niche to facilitate their own growth and evade chemotherapy. Here, we provide evidence that acute myeloid leukemia (AML) blasts remodel the BM niche into a leukemia growth-permissive and
Mesenchymal stem cells and osteoblast progenitors can sense the FSS in the bone marrow cavity and the strain on the bone. Osteoclasts are both mechanosensitive cells and the effectors for other mechanosensitive cells. b. The mechanical stimuli placed on bone may include shear stress, hydrostatic ...
Table S1. Analysis of the RNA-Seq Data from Nestin+ BMSCs Obtained from Leukemic iMLL-AF9 and Normal Mice, Related to Figure 4 Table S2. Analysis of the RNA-Seq Data from Leukemic BM lin− ckitlo Cells Obtained from Mice with/without Nestin+ Cell Depletion, Related to Figure 4 Tabl...
Exosomes were isolated from the conditioned medium of MM1.S cell line and from bone marrow (BM) plasma samples of MM patients. The murine cell line RAW264.7 and primary human CD14+ cells were used as osteoclast (OC) sources. Results We found that AREG was specifically enriched in exosomes...
We describe outcomes after human leukocyte antigen-matched sibling bone marrow transplantation (BMT) for 179 patients with β-thalassemia major. The median age at transplantation was 7 years and the median follow-up was 6 years. The distribution of Pesaro risk class I, II, and III categories wa...
It plays an important function in body support, tolerance of force damage and the protection of internal vital organs, as well as providing a stable circulation environment for the bone marrow [1,2,3,4]. Normally, bone has a certain regenerative potential over time in the face of minor ...
bone marrow;hypoxic microenvironment;cell culturing;bone disease bone-on-a-chip platform 1. Introduction All organs of the human body are exposed to different oxygen tensions, and some organs are exposed to very low oxygen levels and different oxygen gradients. The changes of the bone marrow hypox...
ContextImmunochemical staining of sentinel lymph nodes (SLNs) and bone marrow identifies breast cancer metastases not seen with routine pathological or
The established interaction between multiple myeloma cells and bone marrow microenvironment components provides malignant cells with various survival, growth and drug resistance signals. As a new concept, identification of miRNAs and their related gene/protein targets, signaling molecules and pathways in the...
Recombinant human bone morphogenetic protein 2 (rhBMP-2) and human bone marrow mesenchymal stromal cells (hBM-MSCs) have been thoroughly studied for research and translational bone regeneration purposes. rhBMP-2 induces bone formation in vivo, and hBM-MSCs are its target, bone-forming cells. In ...