Taken together, it appears that the acetylation status of KLF5 switches PCa cells between drastically different states. One is the epithelial state induced and maintained by deacetylated KLF5, in which cells are more rapid in proliferation and tumor formation, ineffective in the induction of bone ...
Therefore, it is reasonable to argue that the foundation for the complex bone marrow microenvironment in adult has been laid at this time. Postnatal MPs support bone growth and homeostasis maintenance Secondary ossification center (SOC) postnatal formation Unlike POC formation which occurs in embryonic...
The formation of an amorphous calcium phosphate (ACP) phase is one of the oldest hypotheses. It was based on the improvement of the crystallinity of bone mineral apatites with time (XRD and FTIR data) (Termine and Posner, 1966), which appeared analogous to the amorphous-apatite conversion of...
The concept that bone formation and resorption are coupled during the bone remodeling process was developed more than 30 years ago. It is based on the principle that bone resorption occurs in order to release calcium for physiological needs and to reshape the bone structure to equip it better ...
occurs over a span of 4-6 weeks. Hence, the effect of the PRP is almost negligible as far as bone healing is regarded. This makes it imperative to deliver the PRP in such a manner that the GFs may able to be sustained over the period of bone regeneration. Studies have employed the ...
two weeks after the fracture occurs. In this stage, proteins produced by the osteoblasts and chondroblasts begin to consolidate into what is known as asoft callus. This soft, new bone substance eventually hardens into ahard callusas the bone weaves together over a 6- to 12-week time period...
Bone formation occurs through the related, but distinct processes of intramembranous and endochondral ossification [1, 2]. While the former is responsible for the formation of bones directly from precursor cells, such as the majority of the skull, the latter is responsible for the development of ...
(Fig.2). This process of bone formation occurs through two basic mechanisms. The first is intramembranous bone formation, when bone forms inside the mesenchymal membrane (ex., skull and jaw); this forms a woven bone, a bone form with randomly organized collagen fibers that are further ...
bone formation [7]. Hence, vascularization occurs from the ossification centers toward the growth plate and determines the rate of bone ossification [8]. It is interesting to note that many of the processes that occur during long bone formation are recapitulated during fracture healing [9], ...
Adipocyte differentiation of bone marrow mesenchymal stem/stromal cells (BMSCs) instead of osteoblast formation contributes to age- and menopause-related marrow adiposity and osteoporosis. Vascular calcification often occurs with osteoporosis, a contradictory association called “calcification paradox”. Here ...