while those with high bone mineral density tend to have strong bones.Much of the formation of bones takes place in one's childhood and teen years, so it is important to take in the right nutrients from a young age.Bone density naturally declines as people age. The production of new bones...
Define bone formation. bone formation synonyms, bone formation pronunciation, bone formation translation, English dictionary definition of bone formation. n. 1. a. The dense, semirigid, porous, calcified connective tissue forming the major portion of the
A key component of MM growth involves the initiation of a feed-forward vicious cycle leading to reduced bone formation and enhanced osteoclastic bone destruction (Fig. 1a). MM is also known to interact with several cellular components of the bone ecosystem such as MSCs2,16. To incorporate thes...
Blood vessels form a versatile transport network that is best known for its critical roles in processes such as tissue oxygenation, metabolism and immune surveillance. The vasculature also provides local, often organ-specific, molecular signals that cont
Since ADAMTS5 deficient mice are protected from cartilage damage, and since it is well known that changes in subchondral bone occur in OA, we questioned whether the differences found in cartilage damage between WT and ADAMTS5 deficient mice are also reflected in the subchondral bone structure of ...
While later in life, due to the formation of SOC which alters the local microenvironment, a stem cell niche is progressively created in the growth plate. PTHrP/PTHLH, a protein member of the parathyroid hormone family, was discovered as a marker for SSCs residing at the borderline chondrocytes...
Bone formation is the fourth phase. Osteoblasts deposit osteoid and lay down concentric lamellae leaving a centralized Haversian canal to serve as a pathway for blood vessels and nerves. The fifth phase, mineralization, involves the calcification of the secreted osteoid. Over 60% of the osteoid bec...
Iron is the most abundant essential metal in mammals and plays a critical role in many physiological processes. For example, iron is involved the formation of the iron porphyrin complex known as heme, and other roles played by iron depend largely on its highly efficient electron transfer propertie...
Successful osteointegration relies upon bone formation, which may originate from the implant surface properties: chemical and physical design, this is referred to as “contact osteogenesis”, as well as from the bony margin of the surgical defect i.e. “distance osteogenesis”2. In our study, whe...
little is known about the role of histone demethylases in osteoclast formation. Here, we identified KDM4B as an epigenetic regulator of osteoclast differentiation. Knockdown of KDM4B significantly blocked the formation of tartrate-resistant acid phosphatase-positive multinucleated cells. Mice with myeloid...