HIV+ cases included more Aboriginal and Black women (12.5% and 16.2 vs. 2% and 1%, respectively), smoked and used injection drugs (53%) more, were more often treated with glucocorticoids, had oligomenorrhea, and reported 10-kg weight cycling. Significantly more HIV+ women reported lifetime ...
FERRARIS SARAVERNE' ENRICABERGUI MAUROONIDA BARBARAMIOLA MARTAVITALE BROVARONE CHIARABAINO FRANCESCOTALLIA FRANCESCA
Osteoporosis is a global health problem for ageing populations. The goals of osteoporosis treatment are to improve bone mineral density (BMD) and prevent fractures. One major obstacle that remains a great challenge to achieve the goals is how to select t
There are currently several approved therapies to treat MM including, but not limited to, proteasome inhibitors (e.g., bortezomib and carfilzomib), chemotherapy (e.g., melphalan), immunomodulatory drugs (e.g., lenalidomide), and cellular and non-cellular immunotherapies (e.g., B cell ...
However, GLP-2r KO mice at 6 weeks of age exhibited also a significant reduction in bone mass and density suggesting a strong role of GLP-2 receptor signaling in controlling bone development and physiology. These results may seem discordant from ours, but it is important to bear in mind ...
These cells were inoculated in a culture flask at a density of 4.0 × 104 cells/cm2 in complete medium (10% fetal bovine serum, glutamine, and 1% penicillin–streptomycin) at 37 °C with 5% CO2 in an incubator. Every 2–3 days, the medium was replaced with fresh complete medium....
have been shown to favor bone formation [156], while capillary density is promoted when pore sizes are greater than 300 μm [130]. For these reasons, solid freeform fabrication (SFF) or additive manufacturing (AM) techniques are attracting great interest, owing to their capabilities of ...
Small interfering RNA (siRNA) against OPN by intratumoural injection significantly suppressed breast tumor growth and angiogenesis in the mouse model [124]. However, siRNA drugs also have the characteristics of high molecular weight and high electronegativity, which poses challenges for delivery [125]...
Using a point grid, the bone marrow adiposity (adipocyt volume density) was estimated as the total number of points hitting adipocytes within the bone marrow divided by total number of point hitting the bone marrow. Adipocytes were defined as cells containing a single large lipid droplet surrounde...
metabolic control of hyperglycaemia via the long-term infusion of insulin preserved bone mineral density and lowered fracture risk in diabetic patients.196,197Moreover, pharmacological intervention by metabolic regulators has been reported to restore impairment of BMMSC-mediated osteoblastogenesis and allevi...