so measurement is appropriate in her case. Her bone mineral density reveals afemoral neckT score of −4.0 and her Z score is −2.3 (Fig. 5.6). Her T score confirms that she has osteoporosis (being below −2.5). However, since her Z score is also considerably below what is expected...
Bone mineral density assessment by DXA to assess efficacy and safety of new drugs in rats and monkeysAnimal models are essential for the discovery and development of therapeutic approaches which act on bone growth and resorption. In our laboratories we have established and validated techniques for ...
Osteoporosis, as a systematic skeletal disorder, is a common age-related bone defect which affects women more than men. Osteoporosis cause bone mineral density (BMD) loss and the degradation of the bone microstructure due to an abnormal imbalance between bone formation by osteoblasts and bone resorp...
Boyd SK, Matyas JR, Wohl GR, Kantzas A, Zernicke RF: Early regional adaptation of periarticular bone mineral density after anterior cruciate ligament injury. J Appl Physiol. 2000, 89: 2359-2364. CAS PubMed Google Scholar Oliveria SA, Felson DT, Reed JI, Cirillo PA, Walker AM: Incidenc...
MicroCT measurement of the tibias and fibulas further confirmed that DkkMo reduced a tumour-associated drop in bone mineral density (Fig. 5c, left) and absorptive destruction of the bone tissue (Fig. 5c, right). Osteolytic activity of MOSJ-Dkk-1 cells was widespread in untreated and DRB-...
Osteoporosis is one of the most common metabolic bone disease among pre- and postmenopausal women. As the precursors of osteoclast cells, circulating monocytes play important role in bone destruction and remodeling. The aim of study is to identify potent
Certain ADHD Drugs May Lower Bone DensityDa Hee HanPharmD
The bone mineral density of patients was measured at month 0 (0 M; baseline) and month 3 (3 M; after three-month intervention). Blood and fecal samples were collected 0 M and 3 M. Only 15 and 12 patients from Probio-M8 and placebo groups, respectively, provided complete fecal samples ...
Bone mineral density Children Adolescents Reference values Dual Energy X-ray Absorptiometry Mexican Bone health Bone mineral apparent density 1. Introduction Bone health is determined by both non-modifiable factors (e.g. genetics, sex and ethnic ancestry) and modifiable factors (e.g. lifestyle, diet...
Genome-wide association studies (GWASs) for osteoporotic traits have identified over 1000 associations; however, their impact has been limited by the difficulties of causal gene identification and a strict focus on bone mineral density (BMD). Here, we use Diversity Outbred (DO) mice to directly ...