Meanwhile, cartilage is a connective tissue that provides major support in bone tissue. Exosomes derived from BMSCs significantly attenuate the inhibitory effects of IL-1β on chondrocyte proliferation and migration, as well as downregulation of COL2A1 and ACAN, and upregulation of MMP13 and ADAMTS...
connective tissue growth factor, FGF: fibroblast growth factor, BMP: bone morphogenic protein, FAK: focal adhesion kinase, PI3K: phosphatidylinositol 3-kinase, JNK: c-Jun amino-terminal kinase, MMP: matrix metalloproteinase, IFT80/88: intraflagellar transport 80/88, COLX: type X collagen, RUNX2:...
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To date, tissue engineering has dominated attempts to construct functional bone scaffolds that can recruit stem/progenitor cells in situ and provide a microenvironment that induce their osteogenic differentiation for endogenous bone regeneration. This approach can circumvent problem such as in vitro ...
visible in the material area, while the scaffold components of PAA and CMC remained invisible. After 14 days of implantation, large TDM particles could still be observed in the implantation area. Most of the small mineral particles were wrapped in fibrous connective tissue and decomposed gradually....
Inherent limitations of bone assessments in radiographs have to be considered when drawing conclusions from measurements that represent remodeling in periodontal lesions after therapy. Both bone quantity and quality seem to be of secondary importance with respect to the progression of disease, as well ...
The role for epigenetic modifications of gene expression in the most common bone diseases is illustrated by drawing on the latest publications in the field. In multifactorial bone diseases such as osteoporosis, many epigenetic biomarkers, either alone or in combination, have been associated with bone...
considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone tissue. In this review, we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to ...
Fig. 1: Preparation of functional tissue-engineered bone-like grafts. A Step-by-step procedures for preparing functional tissue-engineered bone-like grafts. B Schematic drawing of transplantation procedure. Full size image Morphology and stemness of EMSCs isolated from the nasal mucosa before and af...
HB host bone; CT connective tissue; NB newly formed bone. The red arrows in a–c point to the blood vessel Full size image Conclusion In summary, by co-electrospinning PDA NPs with a bioinert synthetic polymer, we constructed bioinspired, flexible, and osteopromotive PDA/PCL fibrous membranes...