Low bone mineral density (BMD) is a major determinant of osteoporosis and is under strong genetic control. A large number of linkage and association studies for BMD variation have been conducted, with the results being largely inconsistent. Linkage exclusion analysis is a useful tool for gene ...
(TNF-α) play an important regulatory role in the developmental process of cancer pain. IKKβ is a key molecule of the IκB (IKK) kinase that propagates cellular responses to inflammation. Previous studies have shown that phosphorylation and degradation of the IκBα protein promotes the ...
Background and Aims Approximately 85% of patients with cancer suffer severe metastatic bone pain for which radionuclide therapy has been employed for pain palliation. We undertook this study to evaluate the pain relief effect of 153Sm-EDTMP in Mexican patients with severe and painful bone metastase...
I am not saying that doctors are not human and that they are immune from diseases. Of course an oncologist can also be afflicted by cancer like anyone else. However, when an oncologist dispenses How To advice, we would expect that the probability of him diagnosing himself at an early treat...
Osteoarthritis comprises several joint disorders characterized by articular cartilage degeneration and persistent pain, causing disability and economic burden. The incidence of osteoarthritis is rapidly increasing worldwide due to aging and obesity trend
In a paper published in the journal Pain, Saint Louis University researcher Daniela Salvemini, Ph.D., reports discovering a key molecular pathway that drives cancer-related bone pain while providing a potential solution with a drug that already is on the
determine whether patients with painful bone metastases from primary cancer sites showed a higher level of a bone resorption marker than those with no evidence of skeletal-related events, and to clarify the efficacy of oral administration of etidronate for pain due to bone metastases and bone ...
March 6, 2024 ByLee Landenberger No Comments The biosimilars revolution continues with the U.S. FDA’s approval of the first denosumab biosimilars: Wyost (denosumab-bbdz) and Jubbonti (denosumab-bbdz) from Sandoz Inc. for treating osteoporosis and to prevent bone problems in cancer. The appr...
153Sm-EDTMP for pain relief of bone metastases from prostate and breast cancer and other malignancies. Arch. Med. Res. 45 (4), 301-308.Correa-Gonzalez L, Arteaga de Murphy C, Pichardo-Romero P, Pedraza-Lopez M, Moreno- Garcia C, Correa-Hernandez L. 2014 153Sm-EDTMP for pain relief ...
In this review, we summarize the current understanding of the mechanism of bone metastases. Based on the general process of bone metastases, we specifically highlight the complex crosstalk between tumor cells and the bone microenvironment and the current management of cancer bone metastases....