Bone pain occurs following a variety of injuries and diseases including; bone fracture, osteoarthritis, low back pain, orthopedic surgery, fibrous dysplasia, rare bone diseases, sickle cell disease, and bone cancer. In the past two decades, significant progress has been made in understanding the ...
Cancer stem cells: Recent insights and therapies HongyuZhou, ...Xin-YuanGuan, inBiochemical Pharmacology, 2023 1Introduction Cancers have become the main cause of death, threatening human life worldwide. Currently, traditional therapeutic strategies developed for cancer treatment, e.g., surgical resecti...
The multifaceted cancer syndrome per se has a deleterious effect on bone. Once a SRE is suspected in a patient, the process of establishing a diagnosis for proper management has to be carried out .Investigations fall into two main categories, radiological and biochemical. They are useful in ...
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et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality—a review of recent evidence. Autoimmun. Rev. 12, 976–989. https://doi.org/10.1016/j.autrev.2013.02.004 (2013). Article CAS PubMed Google ...
The most common site of metastasis in breast cancer is the bone, where the balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation is disrupted. This imbalance causes osteolytic bone metastasis in breast cancer, which l
Since orthotopic human xenograft models of breast cancer are poorly metastatic to bone and experimental models bypass the formation of a primary tumor, however, the precise contribution of tumor-specific αvβ3 to the spontaneous metastasis of breast tumors from the mammary gland to bone remains ...
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer Genetic overexpression of protein deacetylase Sir2 increases longevity in a variety of lower organisms, and this has prompted interest in the effects of it... D Herranz,M Mu?Oz-Martin,M Ca?Amero,... - 《Natur...
J. in Stem Cells and Cancer Stem Cells Vol. 1 (ed M.A. Hayat) Ch. 21, 173–179 (2012). Barry, F. P. Biology and clinical applications of mesenchymal stem cells. Birth Defects Res. C Embryo Today 69, 250–256. https://doi.org/10.1002/bdrc.10021 (2003). Article CAS PubMed ...
numerous pathological conditions related to metabolic dysregulation,3including cancer,4neurodegenerative disorders,5aging,6and bone-related diseases.7Under physiological conditions, autophagy is responsible for the removal of damaged or excessive organelles, whereas under pathological conditions, autophagy helps ...