The growing list of potential, although not yet clinically recognized off-target effects, also includes joint diseases. It has been shown that sclerostin improves posttraumatic osteoarthritis [21] and that synovial fibroblasts producing sclerostin have an inhibitory effect on progression of the TNFα-...
bone mass and integrity are maintained through bone resorbing osteoclasts, and bone forming osteoblasts. Bone remodeling takes place in the Haversian system through the coordinated effort of basic multicellular units
Multimodal approach to treatment has led to the dramatically improved outcome of patients with osteosarcoma and Ewing sarcoma. However, despite intensive therapies and incorporation of novel agents in trials, the therapeutic plateau in recurrent osteosar
Adipose tissue (AT) has multiple roles in body energy balance, regulation of food intake, immunomodulation and growth and functioning of the reproductive organs[1]. In recent years, the understanding of AT functioning has evolved from considering it a lipid storage, cushioning and thermal insulating...
1. Lab for Bone Metabolism, Xi'an Key Laboratory of Special Medicine and Health Engineering; Key Lab for Space Biosciences and Biotechnology, Research Center for Special Medicine and Health Systems Engineering, NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern ...
To assess the differentiation potential of MSCs, 40,000 cells/ml were cultured in 24-well plates (Greiner, Monroe, NC, USA) with coverslips for performing morphological studies. When differentiation was initiated, the entire culture medium was removed and replaced by induction medium (specific for...