The adjuvant core is optionally substituted such that the substitution pattern around the adjuvant core is not particularly limited, as long as the 2-amino nitrogen moiety remains unsubstituted. In some embodiments, the immunoconjugates of the invention are of the formula: wherein the adjuvant core...
The locking nut and bolt system utilizes a bolt with thread having a plurality of notches generally longitudinally spaced in a predetermined pattern. Each notch has a lock face and
TNFα secretion was measured by cytokine bead array (cells gated on viable CD45+CD11c+HLA-DR+) for trastuzumab (dotted line, circle), trastuzumab+Compound 7 (dashed line, triangle) or Immunoconjugate A (solid line, square). FIG. 1G shows the effect of Immunoconjugate A on myeloid ...
The locking nut and bolt system utilizes a bolt with thread having a plurality of notches generally longitudinally spaced in a predetermined pattern. Each notch has a lock face and
do is the diameter of the circle of influence of the rock bolt in the rock, such that outside of this diameter the influence of the bolt disappears (a representative value of ten times the dg was used, as per [16] (m)) ε(x)=ab11+e−x−x0bεx=ab11+e−x−x0b (3...