概要 叔丁氧基羰基保护基(tert-butoxycarbonyl, Boc)、它经常用于通过形成氨基甲酸酯来保护胺基。特别是,它被用作胺保护基的主要选择。在某些情况下,它还用于酒精和苯酚上羟基的保护基。 对于强碱条件下的酯水解条件・亲核条件・接触还原条件・弱的氢化物的还原条件耐受性好,脱保护通常在强酸性条件下进行。因此,...
1) Boc protecting group Boc保护基 例句>> 2) Boc-protected amino acid Boc保护氨基酸 1. An efficient and economical technology for the anchoring ofBoc-protected amino acids via the carboxy terminal to chloromethyl Merrifield resin, using K2CO3/KI as the base reagent, was investigated. ...
A mechanism to explain loss of the Boc group under basic reaction conditions is proposed.doi:10.1016/S0040-4039(00)73512-XTimothy P. CurranElsevier BVTetrahedron LettersCurran, T. P,Pollastri, M. P,Abelleira, S. M. et al.Loss of theTert-butyloxycarbonyl (Boc) Protecting Group under Basic ...
The mechanism of action of BOC-ALLO-ILE-OH in peptide synthesis is based on its ability to form a temporary protective group around the amino acid, preventing unwanted reactions from occurring. This allows for the selective synthesis of peptides with desired sequences. Storage Conditions Store...
The mechanism of action in peptide synthesis involves the stepwise addition of amino acids to form a peptide chain. Storage ConditionsStore in a cool and dry place. View all 4. Computed PropertiesMolecular Weight:304.34g/mol Molecular Formula:C16H20N2O4 Compound Is Canonicalized:True Exact Mass...
Bond Formation: N-BOC group Deprotection Reagents: Strong Organic Acid (TFA, p-Toluenesulfonic Acid), DCM Reactant: N-BOC Protected Amine Product: 1° or 2°Amine Mechanism Top Citations A Simple and Eco-Sustainable Method for the O-Boc Protection/Deprotection of Various Phenolic Structures...
【性质简介】:BOC polyethylene glycol amino, also commonly referred to as t-Boc PEG2-NH2, is a highly common compound in organic synthesis. Its reaction mechanism deeply involves the reactivity of amino groups and the stability of BOC (tert butoxycarbonyl) as a protective group. Firstly, let'...
Protecting groups for peptide syntheses should be stable to acids and bases, and yet removable under mild conditions. These requirements are satisfied by the TCBOC group; deprotection is accomplished with the supernucleophile lithium cobalt(I)-phthalocyanine (Li[Co(I)Pc]) or with zinc in glacial...
【性质简介】:BOC polyethylene glycol amino, also commonly referred to as t-Boc PEG2-NH2, is a highly common compound in organic synthesis. Its reaction mechanism deeply involves the reactivity of amino groups and the stability of BOC (tert butoxycarbonyl) as a protective group. Firstly, let'...
应用介绍:A piperidine derivative with an amine protecting group used in the preparation of biologically active compounds such as antagonists of the human P2X7 receptor and selective irreversible inhibitors for bruton's tyrosine kinase. 公司简介