名称:pGel 水凝胶负载间充质干细胞来源的外泌体(BMSCs-EVs) 说明:Pgel是一种基于肽的水凝胶,它具有优良的生物相容性和生物降解性。Pgel通过自组装形成的三维网络结构能够提供一个适宜的微环境来支持细胞和生物分子的存活和功能。间充质干细胞来源的外泌体(BMSCs-EVs)是由间充质干细胞(BMSCs)释放的小型膜囊...
低硬度的HAMA水凝胶包裹骨髓间充质干细胞分泌细胞外囊泡BMSCs-EVs 外周神经损伤(PNI)是一种常见的神经系统疾病,传统治疗方法效果有限。间充质干细胞来源的外泌体(BMSCs-EVs)已被证实在神经修复中具有潜力,但其体内递送和稳定性仍需改进。有研究者通过开发HAMA水凝胶来优化BMSCs-EVs的递送,提升其在外周神经损伤...
科学家们首先从多个数据库中筛选出与铜死亡相关的LncRNA,通过复杂的机器学习算法,锁定了MAGI2-AS3这一关键分子。接着,他们利用BMSC衍生的EVs作为载体,将MAGI2-AS3送入结直肠癌细胞,观察其对细胞增殖、迁移和侵袭的影响。 在实验过程中,科学家们精心设计了多组对照实验,利用AbMole的CHX等高质量试剂,通过EdU增殖实...
骨质疏松症中 BMSCs-EVs 通过 PI3K/Akt 信号 通路促进成骨分化的研究进展doi:10.3969/j.issn.1002-266X.2022.34.020吴思友何斌祝紫兰梁宁唐小勇Shandong Medical Journal
Examining the communications in the tumor microenvironment (TME) specific to hepatocellular carcinoma (HCC), this exploration looks into the role played by beta-1,4-Galactosyltransferase III (B4GALT3) in bone marrow mesenchymal stromal cell-derived extracellular vesicles (BMSCs-EVs) regarding the NF...
间充质干细胞来源的外泌体(BMSCs-EVs)已被证实在神经修复中具有潜力,但其体内递送和稳定性仍需改进。有研究者通过开发HAMA水凝胶来优化BMSCs-EVs的递送,提升其在外周神经损伤(PNI)治疗中的效果。低硬度的HAMA水凝胶是基于硫醇化透明质酸甲基丙烯酸酯(HAMA)的光交联型水凝胶,具有优良的生物相容性和可调节的机械...
In the PFD model, BMSC-derived EVs significantly reduced the levels of inflammatory cytokines (p<0.05), improved tissue repair, and mitigated neutrophil infiltration. Furthermore, EVs promoted cell proliferation, decreased expression of relaxin receptors, increased expression of elastin, an...
Th17 cellsIn our previous studies, we found that extracellular vesicles in mesenchymal stem cells can alleviate ulcerative colitis. In view of the fact that extracellular vesicles have the same immunomodulatory effects as their maternal cells and considering the important role of Th17 cells in the ...
The focus was on the role of MAGI2-AS3, delivered by BMSC-EVs, in regulating USP6NL DNA methylation-mediated MYC protein translation modification to promote CDK2 downregulation. Utilizing bioinformatics analysis, we identified significant enrichment of MAGI2-AS3 related to copper-induced cell death...
Diagram depicting the alleviating actions of BMSC-EVs in TNBS-induced colitis.Jia YangXingXing LiuHeng FanQing TangZheXing ShouDongMei ZuoZhou ZouMeng XuQianYun ChenYing Peng