CaseinKinase作⽤通路:PROTAC;CellCycle/DNADamage;StemCell/Wnt储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性BMS-986397cereblon的CK1α(酪蛋⽩激酶1α)分⼦胶降解剂,可导致TP53野⽣型AML(急性髓性⽩⾎病)细胞快速凋亡和细胞周期停滞[1]。
BMS-986397No English name English Alias: 2564486-44-6;1H-Isoindole-5-carboxamide, N-[(1R)-1-(3-chloro-2-pyridinyl)-2,2,2-trifluoroethyl]-2-[(3S)-2,6-dioxo-3-piperidinyl]-2,3-dihydro-1-oxo-;SCHEMBL22713266;EX-A8868;DGAWFEDONPXNNP-WMLDXEAASA-N;N-[(1R)-1-(3-chloropyridin-2...
Additionally, single- and repeat-dose toxicity studies in rats, monkeys and primary human samples were executed to determine the CK1α on-target toxicity and the toxicologic profile of BMS-986397. All preclinical data described above were leveraged and integrated into a PK/PD model to establish ...