Table 9. Pharmacokinetic Profiles of33in Preclinical Species (Mouse, Rat, and Monkey) a aMouse PK, CD-1 mice (n= 4); rat PK, Sprague-Dawley rats (n= 3); monkey PK, cynomolgus monkeys (n= 2). for all 3...
Pharmacokinetics of BMS-986278 in preclinical species plasma clearance ((mL/min)/kg) V ss (L/kg) oral bioavailability (%) T 1/2 (h) plasma protein binding (% free) mouse 37 5.5 70 2.5 31.4 rat 15 3.5 100 4.5 12.6 monkey 2.0 1.6 79 11 0.8 MCE has not independently confirmed the ...