Afimetoran,也称为BMS 986256,CAS号为2171019-55-7,分子式为C26H32N6O,是 toll 样受体拮抗剂,可用于炎症和自身免疫性疾病的研究。Toll 样受体 (TLR) 7 和 TLR8 被激活,是系统性红斑狼疮 (SLE) 疾病病理生理学的一部分,包括狼疮性肾炎 (LN) 和相关自身免疫性疾病,例如干燥综合征。BMS-986256 已...
Afimetoran,也称为 BMS 986256,CAS号为2171019-55-7,分子式为C26H32N6O,是 toll 样受体拮抗剂,可用于炎症和自身免疫性疾病的研究。Toll 样受体 (TLR) 7 和 TLR8 被激活,是系统性红斑狼疮 (SLE) 疾病病理生理学的一部分,包括狼疮性肾炎 (LN) 和相关自身免疫性疾病,例如干燥综合征。BMS-986256 已在狼疮...
BMS-986256 is currently under phase II clinical investigation in patients with systemic lupus erythematosus (SLE) [3, 4]. BMS-986256 efficiently inhibits human (h)TLR7, mouse (m)TLR7, and hTLR8, but not mTLR8, as assessed using InvivoGen's HEK-Blue™ reporter cell lines overexpressing...
Purpose Activation of toll-like receptor (TLR)7/8 by self-RNA induces production of type I interferon and several other proinflammatory cytokines, which may contribute to the pathophysiology of SLE and other related autoimmune diseases. Afimetoran, a potent, selective, oral small-molecule inhibitor...