Afimetoran,也称为 BMS 986256,CAS号为2171019-55-7,分子式为C26H32N6O,是 toll 样受体拮抗剂,可用于炎症和自身免疫性疾病的研究。Toll 样受体 (TLR) 7 和 TLR8 被激活,是系统性红斑狼疮 (SLE) 疾病病理生理学的一部分,包括狼疮性肾炎 (LN) 和相关自身免疫性疾病,例如干燥综合征。BMS-
Afimetoran,也称为BMS 986256,CAS号为2171019-55-7,分子式为C26H32N6O,是 toll 样受体拮抗剂,可用于炎症和自身免疫性疾病的研究。Toll 样受体 (TLR) 7 和 TLR8 被激活,是系统性红斑狼疮 (SLE) 疾病病理生理学的一部分,包括狼疮性肾炎 (LN) 和相关自身免疫性疾病,例如干燥综合征。BMS-986256 已...
1.主要目的:在活动性SLE 受试者中,使用主要通过SLEDAI 评估的狼疮活动度改善的复合指标评估afimetoran 对比安慰剂的疗效 2.次要目的: 使用狼疮活动度改善伴CS 剂量降低并维持在较低水平的复合指标评估afimetoran 对比安慰剂的疗效;使用主要通过BILAG 评估的狼疮活动度改善的替代复合指标评估afimetoran 对比安慰剂的疗...
Background Systemic lupus erythematosus (SLE), a chronic autoimmune disease, is characterized by high clinical and molecular heterogeneity and the presence of autoantibodies with various specificities, including those against DNA and RNA. While steroids, such as prednisolone, are a part of the standard...
BMS-986256 is currently under phase II clinical investigation in patients with systemic lupus erythematosus (SLE) [3, 4]. BMS-986256 efficiently inhibits human (h)TLR7, mouse (m)TLR7, and hTLR8, but not mTLR8, as assessed using InvivoGen's HEK-Blue™ reporter cell lines overexpressing...
Purpose Activation of toll-like receptor (TLR)7/8 by self-RNA induces production of type I interferon and several other proinflammatory cytokines, which may contribute to the pathophysiology of SLE and other related autoimmune diseases. Afimetoran, a potent, selective, oral small-molecule inhibitor...