英文名称: BMS-740808 英文同义词: BMS-740808;1-(3-Amino-1,2-benz[d]isoxazol-5-yl)-3-trifluoromethyl-6-[4-[2-[[(3R)-3-hydroxy-1-pyrrolidinyl]methyl]phenyl]phenyl]-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one;1-(3-amino-1,2-benzoxazol-5-yl)-6-[4-[2-[[(3R)-3-...
BMS-740808 is a highly effective and selective factor X inhibitor. 别名 UNII-LDD74E663F, BMS-740808, BMS740808 化学信息 分子量 588.58 分子式 C31H27F3N6O3 CAS No. 280118-23-2 密度 1.52 g/cm3 储存&溶解度 存储 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shippi...
BMS-740808是通过对吡唑基因子X抑制剂Razaxaban修饰双环吡唑并吡啶酮支架而合成的。特别是对于BMS-740808,在吡咯烷环上引入3(R)-羟基部分导致效力显着增强。BMS-740808还显示出对凝血酶的高亲和力。 BMS-740808 is a highly potent, selective inhibitor of Factor X, with K|i|of 0.03 nM. BMS-740808 is ...
化学名 BMS-740808 分子式 C31H27F3N6O3 CAS号 280118-23-2 结构式图片 SMILES NC1=NOC2=C1C=C(C=C2)N3N=C(C4=C3C(=O)N(CC4)C5=CC=C(C=C5)C6=CC=CC=C6CN7CC[C@@H](O)C7)C(F)(F)F INCHIKEY DFRIQJHMGZBFOM-JOCHJYFZSA-N 别名 7H-PYRAZOLO(3,4-C)PYRIDIN-7-ONE, 1...
BMS-740808 InChIKey: CKBGJURGGKJTHU-UHFFFAOYSA-N BMS-740808 Inchi: InChI=1S/C10H11N3O2/c1-4-5(2)12-9-7(4)8(11)6(3-14)10(15)13-9/h3H,1-2H3,(H4,11,12,13,15) BMS-740808 SMILES: CC1=C(C)N=C2C1=C(C(=C(N2)O)C=O)N 如果您需要其它格式的数据,比如:Reaction File...
These efforts led to the identification of 1-[3-aminobenzisoxazol-5′-yl]-3-trifluoromethyl-6-[2′-(3-( R )-hydroxy- N -pyrrolidinyl)methyl-[1,1′]-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4- c ]-pyridin-7-one 6f (BMS-740808), a highly potent (fXa K i =30pM) with ...
BMS-740808 is a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa.