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were calculated by one-way ANOVA test,n = 6. Data was represented as the mean ± SD. Full size image Next, histological evaluation of CD31 revealed weak and inconsistent signals in the control and acellular treatment groups, indicating poor neovascularization following these treatments (Fi...
6. Considering safety and cost, CG appears to be an alternative therapeutic agent for osteoporosis and bone-related diseases that merits further investigations. Acknowledgments This work was supported by the National Natural Science Foundation of China, China (No. 31400304), the Natural Science ...
Titanium and titanium alloys are widely used to manufacture scaffolds for their high strength-to-weight ratio, good biocompatibility, corrosion resistance and durability, strong osteointegration capability, and low cost [3], [4]. However, disadvantages also exist: the elastic modulus of titanium and ...
However, the use of anabolic agents is limited by cost, subcutaneous injection, and concerns about long term safety10. Complementary and alternative medicines for reducing these limitations might be found in natural products with potential anabolic effects. Studies have attempted to identify natural ...
Despite various therapeutic approaches that exist for the treatment of psoriasis, conventional treatments, such as methotrexate (MTX) and narrow-band ultraviolet B phototherapy (NB-UVB), are still widely used because of their cost-effectiveness in reducing proliferation and inducing apoptosis of ...
However, the high cost of recombinant BMP2 protein and its adverse effects limit its clinical application, except for a few orthopedic disease treatments [2]. The tertiary structures of proteins are important in terms of drug design and discovery. Based on the tertiary structure, molecular ...
Keywords: mesoporous bioactive glass; local drug release; BMP-2; fracture healing; autologous blood clot 1. Introduction Bone is among the few tissues in the adult mammalian organism that can fully regenerate and restore its physiological function (restitutio ad integrum) [1]. However, in the ...
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