Epithelial cancers can arise from BM-derived cells (BMCs) in animal models. We studied whether the same phenomenon can occur in humans. Biopsy specimens from carcinomas and healthy adjacent tissues were obtained from three women who had undergone allogeneic BMT from an HLA-matched brother. Complete...
BM-derived cells that foster tumor growth and their manipulationcolorectal cancerdisease-free survivaloverall survivalprogression-free survivalsurrogate endpointsDespite significant advances in the treatment of hematological malignancies over the previous decades, morbidity and mortality from theses disorders still...
Krause DS. BM derived stem cells for the treatment of nonhemato2 poietic diseases . Cytotherapy, 2000, 4( 6 ) : 503 - 506 .Krause DS. BM-derived stem cells for the treatment of non- hematopoietic diseases. Cytotherapy. 2002;4:503-6....
Bone marrow contains different types of stem cells capable of differentiating into cardiomyocytes. Therefore, we hypothesized that bone marrow contains a lin-c-kit progenitor cell pool with the ability to home to the infarcted region and improve the cardiac function. BM-derived stem cells (BMSCs)...
however, both in preclinical and clinical neurodegenerative conditions, these processes were suggested to be sensitive for interventions with stem cells. Intrathecal interventions with a fresh, not-manipulated (naïve) bone marrow-derived stem cell preparation, after positive selection of pro-inflammatory...
Restoration of SR-BI expression in BM derived cells by BM transplantation reduces diet induced atherosclerosis in SR-BI-null/apoE-hypomorphic mice.Ying PeiXing ChenDina AboutoukMark T. FullerOmid DadooPei YuElizabeth J. WhiteSuleiman A...
相关研究成果以“Monascus pigment-protected bone marrow-derived stem cells for heart failure treatment”为题于2024年9月4日发表在《Bioactive Materials》上(IF = 18)。 图1.基于BMSCs的心力衰竭治疗中红曲色素封装HY的示意图设计 研究方案和结果 封装有HY的PPM的制备与表征 ...
(over 2 years).11 BM-derived MSCs and endothelial progenitor cells naturally produce a variety of cytokines and growth factors to promote the survival of surrounding cells via paracrine mechanisms.14,15 Angiogenesis factors released by BM may have a critical role in repairing islet injury.16 In ...
We have previously shown that bone marrow derived stem cells (BMDSCs) engraft the endometrium in mice and humans and Ischemia/reperfusion injury of uterus promoted BMDSCs migration to the endometrium; however, the role of BMDSCs in Asherman's syndrome has not been characterized. Here a murine ...
In addition, MM BM-MSC-derived exosomes had higher levels of oncogenic proteins, cytokines, and adhesion molecules compared with exosomes from the cells of origin. Importantly, whereas MM BM-MSC-derived exosomes promoted MM tumor growth, normal BM-MSC exosomes inhibited the growth of MM cells. ...