These matrices are used in Bioinformatics to compare amino acids in the alignment procedures. However, the methodology can be used in other applications to discover the intrinsic dimensionality of a wide class of symmetrical matrices. The discovery of the intrinsic dimensionality of substitutions ...
These matrices are used in Bioinformatics to compare amino acids in the alignment procedures. However, the methodology can be used in other applications to discover the intrinsic dimensionality of a wide class of symmetrical matrices. The discovery of the intrinsic dimensionality of substitutions ...
To do that, we revisit the original construction of BLOSUM matrices, and re-interpret them as mutation probability matrices. These probabilities are then used as background frequencies in the revised residue conservation measure./p pConclusion/p pWe show that joint entropy with BLOSUM-proportional ...
The BLOSUM matrices estimate the likelihood for one amino acid to be substituted with another, and are commonly used in sequence alignments. Each BLOSUM matrix is associated with a parameter x-the matrix elements are computed based on the diversity among sequences of no more than x% similar. ...