Meaning Lowering blood pressure may be associated with a lower risk of dementia or cognitive impairment. Abstract Importance The benefit of blood pressure lowering for the prevention of dementia or cognitive impairment is unclear. Objective To determine the association of blood pressure lowering with dem...
Meaning A resting systolic blood pressure that chronically exceeds approximately 120 to 125 mm Hg tends to signal incipient hypertension, irrespective of age. Abstract Importance Given that hypertension remains a leading risk factor for chronic disease globally, there are substantial ongoing efforts to de...
This work was supported through grants of the DFG (CRC1009-TPA4). Author Contributions F.B. and C.K. conceived and F.B. and E.N. performed the experiments. C.K. secured funding and wrote the first draft of the manuscript, which was finalized upon discussions with all authors. ...
The work of JLS and MMBB was supported by the German Research Foundation (DFG) under Germany’s Excellence Strategy – EXC2151 – 390873048 as well as by the Diet-Body-Brain Competence Cluster in Nutrition Research funded by the Federal Ministry of Education and Research (grant numbers 01EA1...
First, the investigation was performed on a tissue-level, meaning an average across heterogeneous cells in each sample. Since DNAm is cell-type-specific, changes in DNAm of the whole tissue might not indicate effects on single cell types [71, 72]. Nold et al. showed that astrocytes ...
11 Limitations and future work The quality of any systematic or meta-analytical review is largely determined by the quality of the primary sources included. Most of the evidence included in this review was evaluated as being weak or moderate and with some risk of bias, mostly due to the preva...
Auscultatory method using a mercury sphygmomanometer: how does it work, what does it measure? If we understand the operational strengths and limitations of BP measurement when conducted via both auscultation using a mercury sphygmomanometer and automation using BPMDs, this will enable greater context...
Funding: This work was supported in part by a grant 2006 SEST 08 01 ÆÆCoquenpathææ from the Agence Nationale pour la Recherche (ANR), by the Region des Pays de la Loire (JLP) and by RAS Presidium grant ''Molecular and cell biology'' (NB). TP ...
Because the performance of the signature was lower in patients with KD seen after the seventh day, further work is required to establish the optimal signature for diagnosis in patients with KD with late presentation. Conclusions The results of our study suggest that KD can be distinguished from ...
Meaning The findings indicate that ongoing antihypertensive therapy throughout late life is an important part of dementia prevention. Abstract Importance The utility of antihypertensives and ideal blood pressure (BP) for dementia prevention in late life remains unclear and highly contested. Objectives To...