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In this work, we have also detected DNA of filarial nematodes in chimpanzee faeces. Twenty-three samples (10%) were found to be positive, all of them characterized as M. perstans by phylogenetic analysis (Figure S3). Some of these sequences varied among them, forming a well-defined sub-...
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Tumor mutational burden (TMB) is being explored as a predictive biomarker for cancer immunotherapy outcomes in non-small cell lung cancer. BFAST (NCT03178552)—an open-label, global, multicohort trial—evaluated the safety and efficacy of first-line targ
which were not ideal for picking up on minute changes. Further research employing a wider variety of markers and techniques will contribute to the clarification of potential alterations in brain tissue. Notwithstanding these drawbacks, our work adds to our knowledge of the critical role P2 × ...
“We have a lot of people from an urban area that come to visit,but it involves a lot of the old traditions.” The nighttime hay ride is one such tradition.Small groups gather under the moonlight on an open wagon filled with hay. The passengers sing as farm horses pull the wagon slow...
The time spent near the familiar stranger 1 and the novel stranger 2 were recorded and compared. New object recognition test This test is utilized to evaluate the recognition and memory function of the mice. The mice were placed in an open chamber (40 cm × 40 cm × 40 cm). ...
Previous work on other members of the cadherin family, in most cases E-cadherin, has shown that these adhesion molecules can control integrin activity48,49. At the molecular level, this has been linked to the small GTPase Rap1, a mediator of integrin inside-out activation10,50. Rap1 can ...
Blood lipids are heritable modifiable causal factors for coronary artery disease. Despite well-described monogenic and polygenic bases of dyslipidemia, limitations remain in discovery of lipid-associated alleles using whole genome sequencing (WGS), partl