Conclusions In this multi-cohort study, we found that the blood epigenomic signature of cardiovascular disease is complex and distinct across populations. However, key findings from the SHS were generalized to the WHI, FHS, and ARIC, indicating that DNAm may help identify individuals at higher ris...
We uncovered a circadian metabolome in human RBCs and also showed circadian rhythms of glycolysis and PPP metabolites, indicating that cellular metabolism may be an integral part of non-transcriptional circadian clocks. RBCs depend on glycolysis for ATP, and on the PPP to maintain the redox balance...
Besides, the pro-oxidant and antioxidant activities of patients in distinct stages of chronic kidney disease are divergent, while hemodialysis patients have the most impaired renal function. Consequently, they have the highest amount of oxidative stress, which contributes to the elevation of serum ...
Enhanced WNK4 degradation is resistant to direct, receptor-independent PKA or PKC activation, indicating that the defect is at the postreceptor level (i.e., not due to reduced activation of angiotensin or vasopressin receptors. Although we did not have kidney-specific NHA2 KO mice available for...
It is considered that NPs with a diameter below 6 nm can be cleared by the kidney, as well as particles between 6 nm and 8 nm according to their charge. View chapter Reference work 2010, Encyclopedia of Materials: Science and TechnologyA. Baeza-Squiban Review article Photothermal conversion ...
and there is intensive work to improve their properties in this regard. Other small molecules use active systems in order to pass through the BBB. Large molecules are not able to passively cross the BBB, thus approaches have been made to fit large molecules into existing transport systems. Cell...
a wrist-cuff device that does not work unless the device is at the heart level has been developed,161but even such devices do not overcome this anatomical issue. However, the wrist-cuff device has a certain merit in terms of convenience. Arm-cuff devices also have some shortcomings, such ...
There were no significant interactions between either SBP or DBP and the HT/AHT status of participants indicating their independence (eTable 14 and eTable 15 in Supplement 1). Discussion Antihypertensive Use and Dementia Risk in Late Life This IPD meta-analysis found that older adults with ...
Since the discovery of metal nanoparticles (NPs) in the 1960s, unknown toxicity, cost and the ethical hurdles of research in humans have hindered the translation of these NPs to clinical use. In this work, we demonstrate that Pt NPs with protein coronas
using networks and causal inference, we sought to examine if genetically determined gene expression identified for the lifespan was also involved with the risk of several chronic human diseases. Thus, by using a multi-pronged approach, the objectives of this work on the lifespan were to: assess...