Department of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, VT, USA Kathryn A. Laprade & James M. Stafford Institute of Experimental and Clinical Pharmacology and Toxicology, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Ger...
Here, we examine the full allelic spectrum with plasma lipids using whole genome sequences and harmonized lipids from the National Heart, Lung, and Blood Institute (NHLBI) Trans-Omics for Precision Medicine (TOPMed) program17,18. We studied 66,329 participants and 428 million variants across mult...
Fig. 2 Deep-coverage WGS identifies genomic variation across the allelic spectrum. Variant counts by allele count/frequency bin within each of the cohorts. Singletons (“AC 1”) and doubletons (“AC 2”) are separately distinguished from allele frequency bins within each cohort. Variants were j...
After fixation and dehydration, brain tissues were infiltrated with LX112 epoxy resin embedding mix (Ladd Research Industries, Burlington VT) and placed in molds to polymerize. Blocks were polymerized at 70°C in an oven overnight and then trimmed and sectioned with a diamond knife on an LKB ...
humanely sacrificed and excluded from the study. Mice were sacrificed by perfusion under terminal anaesthesia 1-week post-surgery. Pimonidazole, a hypoxic marker, was injected 1 h prior to sacrifice (60 mg/kg, I.P., HypoxyProbe Inc., Burlington MA, USA) in conscious mice before CBF ...
Wilhelm Raab, M.D., F.A.C.P., F.A.C.C., F.C.C.P., F.A.C.S.M., Active Emeritus Professor of Experimental Medicine, and Director of the Cardiovascular Research Unit, University of Vermont College of Medicine, and Attending Physician, DeGoesbriand Memorial Hospital, Burlington, Vt....
KYH was partially supported by grant T32 HL007567 from the National Heart, Lung, and Blood Institute (NHLBI). This work was supported by HL086694 from NHLBI, HG003054 and HG011052 from the National Human Genome Research Institute. The funders do not have a role in this study. ...
06-10 Burlington, VT - The Monkey House †=06-11 Montreal, Quebec - Il Motore †=06-12 Toronto, Ontario - NXNE Music Festival †=06-13 Toronto, Ontario - NXNE Music Festival †=06-14 Taylor, PA - Underwood Skatepark †=06-15 Brooklyn, NY - 285...
//github.com/statgen/topmed_freeze3_calling. Variant detection (SNPs and indels) from each sequenced (and aligned) genome is performed by vt discover2 software tool42. The variant calling software tools are under active development; updated versions can be accessed athttp://github.com/atks/...
Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington, VT, USA Timothy B. Plante Department of Medicine, Massachusetts General Hospital, Boston, MA, USA Anna C. O’Kelly & Bruno Urrea Division of Cardiology, Department of Medicine, Johns Hopkins University ...