To provide transcytosis across the BBB, we recombinantly fused the TfR binding moiety (scFv8D3) to either sNEP or a previously described variant of NEP (muNEP) suggested to have higher degradation efficiency of Aβ compared to other NEP substrates, but not per se to degrade Aβ more effici...
Oral administration of LF restored the spermatogenesis disorder in mice fed a DON inclusion diet, a fact confirmed by an examination of the intact testicular spermatogenic epithelium and the larger amount of epididymis sperms, and eliminated the oxidative stress and breakages in adhesion junction ...
Respiration (Resp; from a lower chest respiratory belt transducer) and BP recorded in one low responder (blue trace) and one high responder (red trace) while lying supine at rest (10 min), and during 10 min at the imposed breathing frequencies of 12, 9, and 6 breaths per minute (2 ...
We reasoned that human blood leukemias provide a milieu in which blood cell tumors cocirculate with other autologous blood cell components, including phagocytes such as neutrophils and monocytes. This provides anex vivo, fully human, outbred model in which the balance of targeting tumors with nanopar...