The Swiss Jk(null) alleles deviated from wild-type Jka sequence by a nonsense mutation in exon 7 causing an immediate stop codon (Tyr194stop). The English Jk(null) alleles revealed a genomic 1.6 kilobase pair deletion including exons 4 and 5, the former of which includes the translation ...
A Novel Variant in CMAH Is Associated with Blood Type AB in Ragdoll Cats The enzyme cytidine monophospho-N-acetylneuraminic acid hydroxylase is associated with the production of sialic acids on cat red blood cells. The cat has one major blood group with three serotypes; the most common blood...
Multiple Ca2+/calmodulin-dependent protein kinase genes in a unicellular eukaryote. We purified a Ca2+/calmodulin (CaM)-dependent protein kinase (CaM kinase) from the yeast Saccharomyces cerevisiae with properties similar to mammalian type... Pausch, M.H.,D Kaim,R Kunisawa,... - 《Embo ...
which intracellular localization and degradation is well known to be regulated by Flcn21,22. In the wild-type tail skin, Tfe3 immunoreactivity was abundant in mesenchymal cells, but barely visible in BVs or LVs (Fig.5a, b). However, the VECs and LECs inFlcniΔECmice showed strong expressio...
The CD4CreBcl6flox strain was maintained by breeding the Bcl6flox allele to homozygosity (i.e., Bcl6fl/fl) and breeding the Cre alleles in heterozygous to wild-type matings. The mice used in the experiments were littermates and were on a pure C57BL/6 J genetic background. ...
Polymorphism, Single NucleotideAllelesGraves DiseaseProtein Tyrosine PhosphatasesProtein Tyrosine Phosphatase, Non-Receptor Type 1The lymphoid tyrosine phosphatase (... MR Velaga,V Wilson,CE Jennings,... - 《J Clin Endocrinol Metab》 被引量: 1059发表: 2004年 ...
In some, the determination of blood type or the identification of the serum antibody is a great challenge. These cases often occur in patients chronically exposed to red cell antigens, through transfusion or pregnancy. It is possible that limiting opportunities for potential sensitization could ...
Despite the successful introduction of a frameshift mutation on both alleles, as illustrated in Figure S3, all of the cell lines continued to translate FVIII protein in a form visible by western blot (WB) and FC intracellular analyses. This is probably the result of an alternative splicing mecha...
This is in concordance with the fact that constitutional methylation is mono allelic [25], hence only one allele of the BRCA1 gene is methylated in the carriers, however, in the breast cancer patients, the two alleles are affected (according to Knudsen’s hypothesis of tumor suppressor ...
红细胞血型抗原简介Blood group antigens are surface markers on the red blood 2: Blood group antigens are surface markers on the red blood cell membrane