Highly accurate blood test for Alzheimer’s disease is similar or superior to clinical cerebrospinal fluid tests Nicolas R. Barthélemy, Gemma Salvadó, Suzanne E. Schindler, Yingxin He, Shorena Janelidze, Lyduine E. Collij, Benjamin Saef, Rachel L. Henson, Charles D. Chen, Bri...
Until recently, the diagnosis of neurodegenerative diseases such as dementia, Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS) and traumatic brain injury (TBI) had been made by the combination of evaluating a patient’s clinical p...
Blood-based biomarkers hold great promise to revolutionize the diagnostic and prognostic work-up of Alzheimer’s disease (AD) in clinical practice. This is very timely, considering the recent development of anti-amyloid-β (Aβ) immunotherapies. Several assays for measuring phosphorylated tau (p-tau...
Blood tests may enable more accurate diagnosis of ALS at an earlier stage of the disease. As described in a study by researchers at University of Gothenburg and Umeå University, it involves measuring the blood level of a substance that, as they have also shown, varies in concentration depend...
At AAIC 2019, Nakamura and colleagues reported results of a study aimed at analyzing the plasma biomarker in comparison to brain amyloid PET scans (reflecting Aβ deposition), structural MRI (reflecting brain atrophy), FDG-PET (reflecting glucose hypometabolism)...
The TMB reagent remains one of the more popular used in presumptive tests for blood and is the main constituent of the Hemastix® field test [9,23]. Although Hemastix can be used in the field, it tends to show even more false positives than the other popular presumptive tests [11]. ...
All donated blood is tested before it is used, but it takes time for recent HIV and hepatitis infections to become detectable, which is why most countries ask that higher-risk donors avoid sex for a period of time before giving blood. However, modern screening tests can detect H...
Dr. Hye said: "Blood-based NfL offers a scalable and widely accessible alternative to invasive and expensive tests fordementia. It is already used as a routine assessment in some European countries such as Sweden or Netherlands, and our age-related cut-offs can provide a benchmark and quick ...
The routine clinical practice is based on clinical history and examination, usually accompanied by electrophysiological tests. However, although previous studies have demonstrated the involvement of altered metabolic pathways, biomarker-based monitoring tools are still far from being applied. In this study,...
At the moment, most cancer screening tools are limited to specific areas of the body – for example, mammograms for spotting breast cancer and faecal tests for detecting bowel cancer.Whole-body MRIand CT scans can identify tumours throughout the body, but only once they have grown larg...