The blood-testis barrier - Setchell, Waites - 1975 () Citation Context ...eld developing germ cells from the immune system but also gain complete control of the specific humoral and nutritional environment, essential for germ cell development, in the adluminal compartment (=-=Setchell & Waites...
Blood-testis barrier (BTB), an important testicular structure consisting of connections between sertoli cells, is the target of reproductive toxicity caused by many environmental toxins. In this study, ultrastructure observation and BTB integrity assay results indicated that NiCl2 induced BTB damage. ...
-Barrier Formation: One of the primary functions of sustentacular cells is to form the blood-testis barrier. This barrier protects developing sperm from the immune system and maintains a suitable environment for spermatogenesis. -Support for Spermatogenesis: These cells provide structural support and no...
The blood-testis barrier (BTB) is one of the tightest blood-tissue barriers in the mammalian body. It divides the seminiferous epithelium of the seminiferous tubule, the functional unit of the testis, where spermatogenesis takes place, into the basal and the adluminal (apical) compartments....
Blood-Testis Barrier: The blood-testis barrier is the barrier that prevents immune cells in blood from the germ cells found in the seminiferous tubules, where spermatogenesis occurs. Answer and Explanation:1 The structures that maintain the blood-testis barrier are the tight junctions that occur bet...
Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models Ke Song, Xinyan Yang, Geng An, Xinyu Xia, Jiexiang Zhao, Xiaoheng Xu, Cong Wan, Tianyuan Liu, Yi Zheng, Shaofang Ren, Mei Wang, Gang Chang, Shane J. F. Cro...
function of testosterone/DHT-AR signaling. However, circumstantial evidence exists that AR takes part in barrier regulation, describing AR regulation of the tight junction protein claudin-3 in Sertoli cells of the blood-testis barrier (BTB) (Meng et al.2005). Along this line, it has been ...
During spermatogenesis, immature spermatocytes traverse the blood–testis barrier (BTB) and enter the apical apartment of seminiferous epithelium for further development. This course involves extensive junction disassembly and reassembly at the BTB. P-gl
The fact that PFOS has a long half-life in the body[37] renders it essential to study its effects on the reproductive system. Spermatogenesis is a process that depends on the integrity of the blood–testis barrier (BTB). In the mammalian testis, the BTB is formed almost exclusively by ...
The blood-testis barrier (BTB) maintains a suitable microenvironment for germ cells self-renewal and spermatogenesis by blocking the interference and damage of deleterious substances. Therefore, we hypothesized that BTB abnormalities might be involved in busulfan-induced oligospermia. To verify the ...