For dynamic window scanning of the genome, we implemented the SCANG method34. The SCANG procedure accounts for multiple testing by controlling the genome-wide error rate (GWER) at 0.134. In the dynamic window-based workflow, STAAR-O detected 51 regions significantly associated with at least one...
This was done for two reasons—first we assumed that most of the lead load would be from the pRBCs (28–30) and second because currently the labs do not have a standardized method for testing lead levels in non-RBC blood products. Future studies should be designed to measure the lead ...