A novel smartphone-based detection device was created to detect infectious pathogens directly from diluted (10%) human whole blood. The model pathogen was histidine-rich protein 2 (HRP-2), an antigen specific to Plasmodium falciparum (malaria). Anti–HRP-2–conjugated submicrobeads were mixed with...
As a demonstration, by controlling the type and position of cells on a composite, cell-specific hydrogel scaffold, LCL was used to create perfusable synthetic capillaries in about 30 min. Interestingly, the porosity and stiffness of the cell-specific scaffolds were chosen to test the efficacy o...
Plasmodium falciparum malaria parasites invade and remodel human red blood cells (RBCs) by trafficking parasite-synthesized proteins to the RBC surface. While these proteins mediate interactions with host cells that contribute to disease pathogenesis, th
What is a BDG test? The BDG test isindicated for presumptive diagnosis of invasive fungal (mold) infection. It should be used in conjunction with other diagnostic procedures. A negative test result does not rule out invasive fungal disease....
After exposure of cells to a test compound, the supernatant is collected and the LDH content of the supernatant is determined and compared to controls. The more toxic a compound, the more LDH is present in the supernatant and the more substrate is converted. In certain cases, it has been ...
Thus, the ratio of the speckle size to the pixel size of the camera sensor was approximately 2.2. According to [18], this ratio is sufficient for accurate estimation of speckle contrast values. The camera exposure time was set to 1 ms, and the frame rate was 39 frames per second. For ...
Mold specific T-cells have been described as a supportive biomarker to monitor invasive mycoses and mold exposure. This study comparatively evaluated frequencies and cytokine profiles ofAspergillus fumigatusand Mucorales reactive T-cells depending on environmental mold exposure. Peripheral blood mononuclear ...
Wood lamp examination is a diagnostic test in which the skin or hair is examined while exposed to the black light emitted by Wood lamp. Black light is invisible to the naked eye because it is in the ultraviolet spectrum, with wavelength just shorter than the colour violet. The lamp glows ...
Tears have emerged as a promising alternative to blood for diagnosing diabetes. Despite increasing attempts to measure tear glucose using smart contact lenses, the controversy surrounding the correlation between tear glucose and blood glucose still limits the clinical usage of tears. Herein, we present...
A pharmaceutical composition including as active agent, an antisens oligonucleotide having the sequence SEQ ID NO: 1 in a concentration from about 0.40 mg/ml to about 2 mg/ml and th