These properties, coupled with a functional brain endothelial expression profile and the capability to easily test several repeats with low reagent consumption, make this BBB model highly suitable for widespread use in academic and industrial laboratories....
QC of the libraries was conducted, with the following three steps: (1) preliminary test of the library concentration using Qubit 2.0, (2) test of the insert size using Agilent 2100, and (3) precise quantification of the effective concentration of library using qPCR. The libraries were ...
Significant outliers were determined using the intensity-based Significance B option (two-sided Benjamini-Hochberg test) with a FDR cut-off set to 0.05. The protein list was filtered for reverse hits, proteins that are only identified by site and potential contaminants. In addition, proteins ...
These properties, coupled with a functional brain endothelial expression profile and the capability to easily test several repeats with low reagent consumption, make this BBB model highly suitable for widespread use in academic and industrial laboratories....
The tail suspension test (TST) was conducted on the 23rd day postpartum in a quiet location. Mice were suspended by their tails using adhesive tape approximately 30 cm above the tabletop for 6 min, and the immobility time of the mice was recorded during the following 4 min. The for...
Descriptive statistics were performed to describe the assessed variables. The assumptions required for parametric tests were evaluated using the Shapiro–Wilk test and Levene’s test. The Shapiro–Wilk test was employed to assess the normality of the data distributions, while Levene’s test was used...
Humans interact with virus-infected animal hosts, travel globally, and maintain social networks that allow for novel viruses to emerge and develop pandemic potential. There are key lessons-learned from the coronavirus diseases 2019 (COVID-19) pandemic th