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MR-guided focused ultrasound (MRgFUS) is an emerging technology that can accurately and transiently permeabilize the blood-brain barrier (BBB) for targeted drug delivery to the central nervous system. We conducted a single-arm, first-in-human trial to investigate the safety and feasibility of MR...
The movie earned US$409,000 in Japan during its opening week and entered the Japanese box office at No. 10. It also won the jury L'Écran Fantastique Prize at the Montreal Fantasia Film Festival for its "horrifying Lovecraftian bestiary, as well as attention to textures and lighting." Bam...
We have previously shown that excess B lymphocyte Stimulator (BLyS)/BAFF in plasma and on surface of blood dendritic cells (DC) of HIV-infected progressors coincides with B-cell dysregulations and increased frequencies of “precursor” innate marginal zone (MZ)-like B-cells. In contrast, both ...
The Montreal Cognitive Assessment (MoCA) has been considered a superior screening test to the Mini-Mental State Examination (MMSE) for patients with post-stroke cognitive impairment, particularly in executive function, which may be related to reduction in regional cerebral blood flow (rCBF). In ...
In-person cognitive screening assessments were administered to all participants at baseline and during follow-up by centrally trained and certified examiners at each local site and included a test of global cognitive function (Montreal Cognitive Assessment [MoCA]; range, 0-30), learning and memory ...
Pregnancy status was available only for females between 20 and 44 years of age, and was based on pregnancy test and self-report. Postmenauposal women were identified as those not having menstruated in the last 12 months, because of either menopause or hysterectomy. Some data were missing for...
To quantify the influence of the identified factors on accuracy in the association between sex and accuracy, a mediation analysis was performed. Mediation analyses are used to test how given mediators (factors associated with accuracy) influence the association between an independent variable (sex) and...
With FDG PET, we measured AD-typical glucose hypometabolism as the average standardized uptake value ratio (SUVR), using the pons as the reference region,30 in a previously defined Meta-ROI in Montreal Neurological Institute space31 that recapitulates regions of typical hypometabolism (angular gyrus...
Laura Montermini, Janusz Rak, Edward H. Sargent, and Shana O. Kelley from the University of Toronto and Montreal Children's Hospital have developed a method that selectively identifies mutations common in lung and skin cancer with little-to-no sample preparation. Their work appears inNature Chemi...