Peripheral blood stem cells (PBSCs) are preferentially used as a hematopoietic stem cell source for autologous blood stem cell transplantation (ABSCT) upon high-dose chemotherapy (HDT) in a variety of hemato-oncologic diseases. As a prerequisite, hematopoietic stem cells have to be mobilized into...
Limiting numbers of hematopoietic stem and progenitor cells still present a logistical problem for the ultimate broadness of applicability of cord blood transplantation in adults and in children. Current practice suggests the need for at least 2 × 107nucleated cells/kg recipientbody weightfor successfu...
Pluripotent hematopoietic stem cells are a self-renewing population, giving rise to cells with committed differentiation programs, and are common ancestors of all blood cells. The process of hematopoietic differentiation is shown in Fig. 13-2. Download: Download full-size image Figure 13-2. Classic...
Initial experience with autologous transplantation of 7 days non-cryopreserved peripheral blood stem cells, mobilized with G-CSF, in rhabdomyosarcoma Advanced soft tissue sarcomas in adults are considered as non curable tumours with standard dose chemotherapy. Response to alkylating agents is at least par...
A transcriptomic approach to reveal the presence and quantity of RNA transcripts in a biological sample. Induced pluripotent stem cells (iPSCs). Adult cells reprogrammed to induce an embryonic-like pluripotent state for the purposes of inducing differentiation into a cell type of interest for research...
摘要: Does blood formation in mammalian embryos and adults have separate origins or a common source? The most recent investigations into the question add a further chapter to this long-running story.关键词:Animals Mice Yolk Sac Hematopoietic Stem Cells Cell Lineage Aging Core Binding Factor Alpha ...
et al. Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging. Cell Stem Cell 29, 1273–1284 (2022). Article CAS PubMed Google Scholar Ho, T. T. et al. Aged hematopoietic stem cells are refractory to bloodborne systemic ...
Data on the adequacy of blood pressure treatment in this group are critical for preventive efforts to stem the epidemic of ESRD8 and cardiovascular disease in chronic renal disease.9 The Third National Health and Nutrition Examination Survey (NHANES III) data offer the first opportunity to study ...
3a). Intriguingly, luminal progenitors, the cells of origin of BRCA1-associated breast tumors [78], are particularly sensitive to telomere dysfunction [79]. Therefore, more than 4000 variants concurrently influence one or more blood trait and cancer risk, and regulation of telomere length in ...
Nowadays,peripheral blood stem celltransplantation (PBSCT) is a curative therapy forhematological diseasesand alsomalignancies. The harvested stem cells for transplantation are usually obtained from bone marrow or peripheral blood. The PBSCT, in comparison tobone marrow transplantation, seems to be a bett...