A fourth approach, which will become feasible in the near future, involves sequencing the entire whole exome sequencing (WES) or whole genome sequencing (WGS) of individuals with marked perturbation in blood pressure, and comparing genetic variation between them and closely related individuals with ...
Individuals with whole exome sequence data were selected from the extremes (above upper quartile and below lower quartile) of the systolic and diastolic blood pressure distributions. In total, 42 single-nucleotide polymorphisms (SNPs) associated with extremes of blood pressure were found within . Six...
High blood pressure is a major risk factor for cardiovascular disorders such as coronary heart disease and stroke. Approximately 10 million deaths each year can be attributed to high blood pressure globally1,2. An individual’s risk for high blood pressure is determined by genetic, environmental an...
and then double again, reaching about 357,000 tons a year by 2030—nearly seven times the current level, according to the London-based cobalt-trading company Darton Commodities. On the ground in Congo, the pressure to produce cobalt has reached a...
Normal blood pressure ranges rom 110 to 150 millimeters (as the heart beats) over 60 to 80 millime- ters (as the heart relaxes). Patients with readings that exceed either o these ranges are treated or hypertension (high blood pressure). Readings below either o these ranges indicate ...
requiring only measurements in cuff-pressure changes. Therefore, these devices incorporate only a pressure sensor. Such a simple mechanism makes the device less troublesome and cheaper. The cuff-oscillometric device has another advantage when compared with the microphone device, in that surrounding noise...
expression quantitative trait locus; GE, gene expression; GTEx, Genotype-Tissue Expression project; ICBP, International Consortium for Blood Pressure Genome-Wide Association Studies; IV, instrumental variable; meQTL, methylation quantitative trait locus; Pos, position; SBP, systolic blood pressure; SNP,...
Table 1. Projected Number of Individuals Globally With Systolic Blood Pressure of at Least 110 to 115 mm Hg and of 140 mm Hg or Higher, Deaths, and Disability-Adjusted Life-Years, 1990-2015a View LargeDownload Projected No. (95% Uncertainty Interval) 1990 1995 2000 SBP ≥110-115 mm Hg ...
We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10−11 to ...
Blood pressure (BP) determines whether a person has hypertension and offers implications as to whether he or she could be affected by cardiovascular disease. Cuff-based sphygmomanometers have traditionally provided both accuracy and reliability, but they