B cells produce large numbers of antibodies (also called immunoglobulins or gamma globulins). There are five types of immunogloulins (abbreviated Ig): IgG, IgM, IgE, IgA and IgD. These are Y-shaped molecules that have a variable segment that is a binding site for only one specific antigen...
The German physician Rudolf Virchow observed greatly increased numbers of white blood cells in the blood smear of one of his patients, and coined the term leukemia (meaning “white blood”) to describe this phenomenon. Clinicians of the day subsequently reported that although leukemia was rare, ...
Multigenic models based on this trait predicted the risk of developing chronic kidney disease in type 2 diabetes patients. By expanding the phenotypic space for human genetic studies, we could identify variants associated with large effect response differences, stratify patients and efficiently ...
Our lab has reported miRNA expression patterns in 11 tissues (brain, longissimus dorsi muscle, kidney, liver, spleen, thymus, cerebellum, medulla, hypothalamus, abdominal subcutaneous fat and rump subcutaneous fat) of beef cattle21, which has contributed to the first and up-to-now the most ...
The numbers in the circle correspond to the samples belonging to that bin. Distribution of VB10-Score for the healthy controls is provided in the inset. Further, in the South Indian Cohort (BL-VB) containing 16 confirmed bacterial and 14 confirmed viral infection samples, VB10 scores showed ...
SARS-CoV-2 is capable of infecting human cells through the binding of its surface protein Spike1 to host cell surface proteins. The angiotensin converting enzyme-2 (ACE2) functions as a receptor for the virus and its main gateway. Pulmonary, cardiac, gut cells and body vasculature express hig...
In total, 18 PBMC samples (n = 9 for each group, Additional file 1: Table S1) were transferred into BRGSF mice (Additional file 1: Table S3); the detailed numbers of recipient mice for each donor of PBMCs are provided (Additional file 1: Table S3). In total, 10 PBMC samples ...
(49) have reported reduced responsive- ness to insulin in fetal tissues, despite the presence of increased numbers of insulin receptors in comparison to adult cells. Orig- inally, it was suggested that postbinding hormone-mediated ac- tion required translocation of the hormone-receptor complex to...
HEK293T (human embryonic kidney cell line) cells were cultured in DMEM (Gibco-BRL) supplemented with 10% fetal bovine serum (FBS, Gibco-BRL). Rh D-positive and Rh D-negative peripheral blood cells were supplied by Severance Hospital Blood Bank (Seoul, South Korea). TALENs targeting RHD. ...
The blood–brain barrier (BBB) is a sophisticated structure whose full functionality is required for maintaining the executive functions of the central nervous system (CNS). Tight control of transport across the barrier means that most drugs, particularly large size, which includes powerful biologicals...