Active intravenous drug abuse (aIVDU) can increase susceptibility to blood stream infection (BSI) and allow exposure to HIV and other blood-borne viruses. Age may add another level of vulnerability in co-infecte
Well-regulated induction of immune responses targeting nonself-viral epitopes is beneficial for virus clearance. On the other hand, excessive or aberrant responses to virus infection can resemble those of autoimmune diseases and occasionally pose risks of self-reactive immune responses as in Guillain–B...
BSI bloodstream infection(s) CSI Charlson Severity Index CHZ Calgary Health Zone GI gastrointestinal PUD peptic ulcer disease Keywords Enterococcus faecalis Enterococcus faecium bacterial infections bacteremia VRE outcomes population-based 1. Introduction Enterococcus species are a frequent cause of blood strea...
In our daily management of critically ill patients, we observed that many experienced decreased serum albumin and increased non-renal blood urea nitrogen (BUN) due to factors such as poor nutritional intake, infection, and organ decompensation. This raises the question: Are these changes linked to...
There is increasing evidence for blood–brain barrier (BBB) alterations in Parkinson’s disease (PD), the second most common neurodegenerative disorder with rapidly rising prevalence. Altered tight junction and transporter protein levels, accumulation of α-synuclein and increase in inflammatory processes...
Abbreviations BSI: Blood stream infection; CoNS: Coagulase negative Staphylococci; LRCoNS: Linezolid Resistant Coagulase Negative Staphylococci; LZD: Linezolid Acknowledgments None. Authors' contributions VB, RG: Conceived and designed the experiment, VB, GM, VR: Experimental Work, VB, GM, RG: Data ...
(MS)2,3. In the mouse model, persistent infection by Theiler’s virus causes an autoimmune response targeting myelin via epitope spreading, where self-proteins are aberrantly presented to the immune system4. In systemic lupus erythematosus (SLE) plasma, antibody titers against an envelope protein...
SCOPE, 2003 4937 Randomized, double-blind, placebo control Age, 70-89 y; SBP of 160-179 mm Hg and/or DBP of 90-99 mm Hg Majority primary ARB with or without second antihypertensive drug Placebo 44.6 MMSEb 28.5 (1.6) 28.5 (1.5) ICD-10 criteria Decrease in MMSE score ≥4 Change in ...
]. Similarly, individuals with a CRP measure > 10 mg/L were excluded because this threshold constitutes clinical evidence of an acute infection or inflammatory reaction [35, 36], which could also confound the conclusions concerning cancer risk. Data from 32 individuals who withdrew from the UKBB...
Notably, only patients without clinical signs of infection were included in the study. This finding of innate immune system activation is consistent with evidence of elevated pro-inflammatory cytokines in blood [7] and cerebrospinal fluid (CSF) [21], and increased susceptibility to infections and ...