This assumption might be supported by the threshold character of both myocardial O2 balance and CoPP, meaning that critically low levels have not been reached. However, this observation has to be interpreted with caution, because the difference in O2 extraction has been detected to be significant ...
both susceptibility to and severity of this disease are highly heritable. The major gene association is with the MHC I geneHLA-B27with 95% of patients positive for this gene [2–4]. However, only approximately 5% ofHLA-B27carriers suffer from AS, meaning other genes are involved in disease...
Due to the physiological and structural properties of the blood–brain barrier (BBB), the delivery of drugs to the brain poses a unique challenge in patients with central nervous system (CNS) disorders. Several strategies have been investigated to circumvent the barrier for CNS therapeutics such as...